In the dynamic field of peptide synthesis, researchers continuously seek novel amino acids and building blocks that can impart unique properties to their target peptides. L-1,2,3,4-Tetrahydroisoquinoline-3-carboxylic acid (L-Tic), a non-proteinogenic amino acid, has emerged as a valuable component in this arena due to its rigid, cyclic structure. This article delves into the properties of L-Tic and provides essential guidance for scientists looking to purchase this specialized chemical for their peptide synthesis projects.

Understanding L-Tic's Value in Peptide Chemistry

L-Tic, with its CAS number 74163-81-8, is an unnatural amino acid characterized by its tetrahydroisoquinoline core. When incorporated into a peptide chain, this moiety significantly influences the peptide's three-dimensional conformation. Unlike flexible linear amino acids, L-Tic's constrained structure can lead to:

  • Enhanced Conformational Rigidity: This can stabilize secondary structures such as helices or turns, which is often desirable for improving the biological activity and stability of therapeutic peptides.
  • Increased Proteolytic Resistance: The modified structure can make the peptide less susceptible to degradation by proteases, thereby extending its half-life in vivo.
  • Modulation of Receptor Binding: The specific spatial arrangement conferred by L-Tic can optimize interactions with target receptors, potentially enhancing potency or selectivity.

These characteristics make L-Tic an attractive building block for developing peptide-based drugs, diagnostics, and research tools. Its application spans areas like enzyme inhibitors, receptor agonists and antagonists, and peptide mimetics.

Sourcing High-Quality L-Tic for Synthesis

For successful peptide synthesis, the quality of the amino acid building blocks is non-negotiable. When procuring L-1,2,3,4-Tetrahydroisoquinoline-3-carboxylic acid, scientists and procurement specialists should prioritize suppliers who can guarantee:

  • High Purity: A minimum purity of 97% is generally recommended, with specific requirements for enantiomeric purity often being even more critical.
  • Reliable Manufacturer Data: Reputable suppliers will provide detailed Certificates of Analysis (CoA) outlining purity, identity, and any relevant impurity data, often using techniques like HPLC and NMR.
  • Consistent Availability: Securing a stable supply from a manufacturer known for its production capacity and reliable delivery is key to uninterrupted research or production timelines.
  • Competitive Pricing: While quality is paramount, cost-effectiveness is also a significant consideration. We, as a specialized manufacturer, are dedicated to offering competitive pricing for L-Tic, enabling broader access to this valuable intermediate.

As a leading manufacturer of specialized chemical intermediates, we offer L-Tic to the global research community. We understand the demanding requirements of peptide synthesis and are committed to supplying a product that meets rigorous quality standards. We encourage researchers to buy L-Tic from trusted sources to ensure the success of their synthetic endeavors. Contact us today to inquire about purchasing options and to request a sample of our premium L-1,2,3,4-Tetrahydroisoquinoline-3-carboxylic acid.

By choosing a dependable manufacturer for your L-Tic needs, you invest in the quality and reproducibility of your peptide synthesis projects, ultimately accelerating your research and development efforts.