The field of peptide therapeutics has seen exponential growth, driven by the inherent specificity and efficacy of these biomolecules. Central to the successful synthesis of these complex peptides is the availability of high-quality protected amino acids. Among these, N-Cbz-L-Leucine, identified by CAS number 2018-66-8, stands out as a critical component. As a leading pharmaceutical intermediate supplier, we understand the nuances of sourcing this vital compound for researchers and manufacturers globally.

N-Cbz-L-Leucine, also known as N-Carbobenzyloxy-L-leucine or Z-Leu-OH, incorporates the benzyloxycarbonyl (Cbz) protecting group. This group is instrumental in peptide synthesis, preventing unwanted side reactions at the alpha-amino group while allowing for selective deprotection under specific conditions, often involving catalytic hydrogenation. This precise control is fundamental for building peptide chains with the correct sequence and stereochemistry, a requirement for biologically active peptides and potential drug candidates, including those targeting cancer.

The application of N-Cbz-L-Leucine extends beyond basic peptide chain elongation. It is integral in the preparation of peptidomimetics and in the synthesis of complex pharmaceutical intermediates where an L-leucine residue is incorporated. Its reliable supply is crucial for companies engaged in drug discovery, where the synthesis of libraries of peptide analogs is common. A consistent supply chain from a reputable manufacturer ensures that research timelines are met and development programs are not hindered by material shortages.

For purchasing professionals, securing N-Cbz-L-Leucine at a competitive price is a key objective. When seeking to buy this pharmaceutical material, it's beneficial to work with suppliers who can guarantee high purity (commonly 99%) and provide comprehensive technical data. Many leading suppliers are based in China, offering a robust manufacturing base for such specialized amino acid derivatives. Exploring options for bulk purchase from these manufacturers can significantly reduce overall project costs.

The chemical properties of N-Cbz-L-Leucine, such as its molecular formula (C14H19NO4) and its appearance as a yellow oil or weak solid, are important considerations for laboratory handling and reaction planning. Its solubility in solvents like dichloromethane and ethyl acetate makes it amenable to standard synthetic procedures. When contacting a supplier, be prepared to discuss your specific needs regarding quantity, packaging, and delivery timelines to secure a quotation.

In conclusion, N-Cbz-L-Leucine (CAS 2018-66-8) is more than just a chemical; it's a cornerstone for innovation in peptide science and pharmaceutical development. By partnering with experienced manufacturers and suppliers, particularly those based in China, you can ensure access to high-purity material at attractive prices, thereby supporting your critical research and manufacturing endeavors. Discover how a reliable supply of this essential amino acid derivative can empower your next breakthrough.