Famotidine stands as a cornerstone in the treatment of hyperacidity and related gastrointestinal disorders, and its efficient synthesis is vital for meeting global demand. Central to this manufacturing process is the chemical intermediate, N-Sulphamyl-3-chloropropionamidine Hydrochloride (CAS 106649-95-0). Understanding its role and properties sheds light on why sourcing high-quality material from reliable manufacturers is so crucial for pharmaceutical API production.

N-Sulphamyl-3-chloropropionamidine Hydrochloride, a fine chemical, is more than just a precursor; it is a precisely engineered molecule designed to undergo specific transformations in the multi-step synthesis of Famotidine. While detailed proprietary synthesis routes vary between manufacturers, the general pathway involves utilizing the reactive sites within this intermediate to build the complex structure of Famotidine. The guanidine moiety and the chloropropyl chain are key features that participate in subsequent cyclization and functionalization steps.

The significance of this intermediate's purity cannot be overstated. A high assay, such as the commonly specified ≥98.0%, ensures that the chemical reactions proceed cleanly, minimizing side reactions and the generation of difficult-to-remove impurities. For procurement managers looking to buy this compound, understanding its structural relevance to the final product helps in appreciating the importance of stringent quality control from the manufacturer. The white or off-white powder appearance is a basic indicator, but the actual chemical purity is determined by analytical techniques like HPLC.

For pharmaceutical R&D scientists, this intermediate might also be explored for process optimization studies or even in the synthesis of related compounds. The availability of reliable suppliers, particularly those based in China, provides access to this critical building block for both large-scale manufacturing and smaller research quantities. When inquiring about N-Sulphamyl-3-chloropropionamidine Hydrochloride, referencing the CAS number 106649-95-0 is imperative for accurate identification.

In essence, N-Sulphamyl-3-chloropropionamidine Hydrochloride is an indispensable component in the production of Famotidine. Its consistent quality and availability directly influence the efficiency, cost-effectiveness, and compliance of the final API. By partnering with reputable manufacturers and prioritizing the specifications of this vital intermediate, pharmaceutical companies can ensure a robust and high-quality manufacturing process.