In the intricate world of pharmaceutical synthesis, the selection of appropriate building blocks and intermediates is fundamental to the success of drug development. The Rolapitant Intermediate, identified by its CAS number 1214741-21-5, stands out as a crucial component in the production of Rolapitant, a potent NK1 receptor antagonist. For researchers and chemists focused on drug discovery and manufacturing, understanding the chemical properties and synthetic utility of this intermediate is essential. Let's delve into its significance and explore why reliable sourcing is so important.

Chemical Identity and Significance

The chemical name 3-(1,1-diMethylethyl)-7a-ethenyltetrahydro-1-hydroxy-(3R,7aR)-3H,5H-Pyrrolo[1,2-c]oxazol-5-one (CAS 1214741-21-5) describes a complex organic molecule featuring a pyrrolo[1,2-c]oxazole core with specific stereochemical configurations (3R,7aR). This intricate structure, often referred to as Rolapitant Intermediate 1, contains key functional groups that are strategically manipulated during the multi-step synthesis of Rolapitant. The presence of the chiral centers and the vinyl group makes it a valuable chiral building block for creating the specific three-dimensional structure required for biological activity.

Synthetic Applications and Utility

The primary application of CAS 1214741-21-5 is its role as a direct precursor in the synthesis of Rolapitant. Pharmaceutical chemists utilize this intermediate to build the final, complex molecular architecture of the drug. The successful conversion of this intermediate into the API depends on several factors:

  • Stereoselective Reactions: The inherent chirality of the intermediate dictates the stereochemistry of subsequent steps. Chemists must employ reactions that maintain or selectively modify these chiral centers, ensuring the formation of the desired enantiomer of Rolapitant.
  • Functional Group Transformations: The hydroxyl and vinyl groups within the intermediate are prime targets for chemical modifications, such as oxidation, reduction, or coupling reactions, to introduce further complexity or specific functional moieties needed in the final API.
  • Process Optimization: Pharmaceutical R&D departments constantly work on optimizing synthesis routes to improve yield, reduce by-products, and lower manufacturing costs. The efficiency with which this intermediate can be processed directly impacts these optimization efforts.

Sourcing High-Quality Intermediates

For researchers and procurement specialists looking to purchase Rolapitant Intermediate manufacturer services, finding a supplier that guarantees consistent quality and purity is paramount. When you buy CAS 1214741-21-5, ensure the supplier provides:

  • Detailed Certificates of Analysis (CoA) confirming purity, stereochemistry, and other critical specifications.
  • Reliable production capacity to meet R&D and potential scale-up demands.
  • Competitive pricing structures suitable for research budgets and commercial production planning.

As a leading pharmaceutical intermediate supplier, we are committed to providing researchers with the high-quality building blocks they need. By ensuring the integrity of intermediates like CAS 1214741-21-5, we contribute to the advancement of pharmaceutical science and the development of effective treatments.