The world of lipids is vast and complex, with phospholipids forming the fundamental structure of all biological membranes. While long-chain phospholipids are extensively studied for their role in membrane stability and fluidity, short-chain phospholipids, such as 1,2-Dibutyryl-sn-glycero-3-phosphocholine, offer a unique set of properties that are invaluable for specific scientific and pharmaceutical applications. NINGBO INNO PHARMCHEM CO.,LTD., a leading manufacturer and supplier of specialty biochemicals, provides high-quality 1,2-Dibutyryl-sn-glycero-3-phosphocholine to researchers and formulators worldwide. This article highlights the characteristics of short-chain phospholipids and the versatility of 1,2-Dibutyryl-sn-glycero-3-phosphocholine.

Understanding Short-Chain Phospholipids

Short-chain phospholipids are distinguished by the presence of short fatty acyl chains attached to the glycerol backbone. In the case of 1,2-Dibutyryl-sn-glycero-3-phosphocholine (CAS: 3355-26-8), these chains are butyryl groups (four carbons each). This structural feature leads to several key differences compared to their long-chain counterparts:

  • Detergent-like Properties: Due to the limited hydrophobic interactions from short chains, these molecules tend to form micelles rather than stable lipid bilayers. This makes them excellent detergents for solubilizing membranes and membrane proteins.
  • High Critical Micelle Concentration (CMC): They require higher concentrations to form micelles compared to long-chain phospholipids, reflecting weaker hydrophobic association.
  • Membrane Solubilization: Their ability to disrupt and solubilize lipid bilayers makes them valuable tools for extracting and studying membrane proteins in their native or near-native states.

Versatile Applications of 1,2-Dibutyryl-sn-glycero-3-phosphocholine

The unique properties of 1,2-Dibutyryl-sn-glycero-3-phosphocholine, typically supplied as a yellow gel-like solid with 98% purity, make it suitable for a range of applications:

  • Membrane Protein Research: Its detergent-like behavior is ideal for isolating and stabilizing membrane proteins for structural and functional studies. This is crucial for understanding the mechanisms of protein function in their native lipid environment.
  • Drug Delivery Systems: As discussed previously, its amphiphilic nature allows for the formation of micelles and liposomes, which are vital for encapsulating and delivering poorly soluble drugs. Pharmaceutical formulators often seek such lipids to improve drug solubility and bioavailability.
  • Cellular Signaling Studies: Its potential to modulate signaling pathways, such as PKC activation, opens avenues for research into cellular communication and disease mechanisms.

Why Partner with NINGBO INNO PHARMCHEM CO.,LTD.?

When you need to buy specialty lipids like 1,2-Dibutyryl-sn-glycero-3-phosphocholine, ensuring quality and consistent supply is paramount. NINGBO INNO PHARMCHEM CO.,LTD. is a dedicated manufacturer and supplier committed to providing high-purity biochemicals. Our product is characterized by its reliable 98% purity, ensuring your research and formulation projects are built on a foundation of quality. As a leading supplier in China, we offer competitive pricing and expert support. For those seeking a dependable source for this versatile phospholipid, NINGBO INNO PHARMCHEM CO.,LTD. is your trusted partner. Contact us today for a quote and to explore our comprehensive range of biochemicals.