As a chemist deeply involved in pharmaceutical research, understanding the functional properties and sourcing of specialized compounds is critical. Quifenadine, known chemically as (3-QUINUCLIDINYL)DIPHENYL CARBINOL HYDROCHLORIDE and bearing the CAS number 10447-39-9, stands out as a significant molecule due to its pharmacological activity. This article delves into its chemical nature, its crucial role as a muscarinic acetylcholine receptor antagonist, and practical advice for chemists looking to buy this compound from trusted global manufacturers.

Chemical Profile of Quifenadine

Quifenadine is characterized by its specific molecular structure, which includes a diphenyl carbinol moiety attached to a quinuclidine ring system. The hydrochloride salt form enhances its solubility and stability, making it suitable for various laboratory applications. Its physical appearance is typically a white to pale beige solid, with a melting point around 239°C. While hygroscopic, it can be reliably stored under inert atmospheres at low temperatures (-20°C freezer). For purchase inquiries, noting these properties is essential for chemists to ensure they are acquiring the correct material for their experiments.

Mechanism of Action: Muscarinic Antagonism

The pharmacological significance of Quifenadine lies in its ability to antagonize muscarinic acetylcholine receptors. Acetylcholine is a key neurotransmitter in the central and peripheral nervous systems, mediating a wide range of physiological functions. By blocking the action of acetylcholine at muscarinic receptors, Quifenadine allows researchers to investigate the specific roles of these receptors in various biological processes. This makes it an invaluable tool for studying conditions affecting the nervous system, such as Alzheimer's disease, Parkinson's disease, and various psychiatric disorders. Scientists frequently buy Quifenadine for use in receptor binding assays, cell signaling studies, and in vivo pharmacological models.

Procurement Strategies for Chemists

For chemists requiring Quifenadine for their research, identifying reliable suppliers is a key step. When searching for a '(3-QUINUCLIDINYL)DIPHENYL CARBINOL HYDROCHLORIDE supplier' or looking to 'buy Quifenadine CAS 10447-39-9', several factors should guide your decision:

  • Purity Verification: Always request a Certificate of Analysis (CoA) to confirm the purity (often advertised as 99%) and ensure it meets your experimental needs.
  • Supplier Reputation: Partner with established chemical manufacturers and distributors known for quality and consistent product specifications. Consider suppliers based in regions with strong chemical production capabilities, such as China.
  • Packaging and Storage: Understand the recommended packaging and long-term storage conditions to maintain the compound's integrity.
  • Technical Support: A knowledgeable supplier can provide technical assistance regarding the compound's properties and applications.

By prioritizing these aspects, chemists can confidently procure Quifenadine (CAS 10447-39-9) from reputable sources, ensuring the integrity and reproducibility of their neurological and pharmacological research. Engaging with leading manufacturers and suppliers facilitates not just the purchase, but also a partnership that supports scientific advancement.