In the sophisticated field of pharmaceutical synthesis, specific chemical intermediates act as the foundational building blocks for life-saving medications. (R)-9-(2-hydroxypropyl)adenine, identified by its CAS number 14047-28-0, is one such critical compound. For R&D scientists and formulation experts, understanding its properties and applications is key to advancing antiviral therapies, particularly in the production of tenofovir.

What is (R)-9-(2-hydroxypropyl)adenine?

(R)-9-(2-hydroxypropyl)adenine is a nucleoside analog intermediate. Its molecular formula, C8H11N5O, and a molecular weight of 193.21 indicate a complex structure that is essential for chiral synthesis. The compound is typically a white to off-white crystalline powder, and its precise stereochemistry, denoted by the (R) designation, is critical for its function in drug synthesis.

A Cornerstone for Tenofovir Production

The primary significance of (R)-9-(2-hydroxypropyl)adenine lies in its role as a key precursor in the synthesis of tenofovir. Tenofovir is a potent nucleotide reverse transcriptase inhibitor (NRTI) widely used in the treatment regimens for Human Immunodeficiency Virus (HIV) infection and chronic Hepatitis B virus (HBV) infection. The multi-step synthesis of tenofovir relies on intermediates like (R)-9-(2-hydroxypropyl)adenine to construct the molecule with the correct stereochemical configuration, which is vital for its biological activity.

Why Sourcing Matters for R&D

For researchers and scientists, the quality and availability of this intermediate directly impact the success of their drug development programs. When you buy (R)-9-(2-hydroxypropyl)adenine, consider the following:

  • Purity for Accurate Research: High-purity material ensures reliable experimental results and minimizes potential confounding factors in drug efficacy studies.
  • Supplier Reliability: Partnering with a reputable manufacturer and supplier that guarantees lot-to-lot consistency is essential for reproducible research.
  • Technical Support: Access to technical data, such as detailed analytical reports and solubility information, from your (R)-9-(2-hydroxypropyl)adenine supplier can accelerate your research process.
  • Understanding the CAS Number: Always reference the correct CAS 14047-28-0 to ensure you are obtaining the precise compound required for your specific synthesis pathway.

The Global Supply Landscape

Many global pharmaceutical companies source essential intermediates from specialized chemical manufacturers. Countries like China are major hubs for the production of these critical compounds. Identifying a trusted (R)-9-(2-hydroxypropyl)adenine manufacturer in China can provide access to high-quality materials at competitive prices, supporting both early-stage research and large-scale commercial production. Companies that specialize in fine chemicals and pharmaceutical intermediates are well-positioned to meet the stringent demands of the global pharmaceutical market.

In conclusion, (R)-9-(2-hydroxypropyl)adenine (CAS 14047-28-0) is more than just a chemical; it's a critical enabler for antiviral therapies. For scientists and researchers, careful selection of suppliers who can provide consistent, high-quality material is a crucial step in the journey from laboratory synthesis to life-saving medicine.