In the intricate world of pharmaceutical synthesis, intermediates play a pivotal role, acting as essential building blocks for complex Active Pharmaceutical Ingredients (APIs). Among these, Rosuvastatin Methyl Ester (CAS 147118-40-9) stands out as a key component in the production of Rosuvastatin Calcium, a widely prescribed medication for managing hypercholesterolemia. For R&D scientists and formulation chemists, understanding the characteristics and utility of this intermediate is vital for successful drug development.

Chemical Profile of Rosuvastatin Methyl Ester

Rosuvastatin Methyl Ester, identified by CAS number 147118-40-9, is an organic compound with the molecular formula C23H30FN3O6S and a molecular weight of approximately 495.56. It typically presents as a white to off-white crystalline powder. Its structure features a pyrimidine core functionalized with a fluorophenyl group and an isopropyl moiety, alongside a hydroxylated heptenoic acid methyl ester chain. This specific arrangement of functional groups is what makes it a crucial precursor in the stereoselective synthesis of Rosuvastatin.

Significance in Statin Synthesis

The primary application of Rosuvastatin Methyl Ester is as a direct intermediate in the manufacturing pathway of Rosuvastatin Calcium. The synthesis involves several steps, and this ester derivative provides a stable and reactive form that can be readily converted to the final carboxylic acid or its calcium salt. Its controlled purity ensures that the subsequent steps proceed efficiently, minimizing side reactions and the formation of unwanted impurities in the final drug product.

Why Purity Matters for Drug Development

For pharmaceutical intermediates like Rosuvastatin Methyl Ester, purity is not just a specification; it's a critical determinant of the final API's safety and efficacy. Even trace impurities can:

  • Interfere with downstream chemical reactions, reducing yield and increasing production costs.
  • Lead to the formation of potentially toxic byproducts that are difficult to remove.
  • Impact the pharmacokinetic and pharmacodynamic properties of the final drug.
  • Cause regulatory hurdles during drug approval processes.

Therefore, sourcing this intermediate from reliable manufacturers who can guarantee high purity (e.g., 99% or higher) and provide thorough analytical documentation, such as Certificates of Analysis, is essential for any pharmaceutical R&D or manufacturing effort.

Sourcing and Commercialization

Companies looking to buy Rosuvastatin Methyl Ester will find that China is a significant manufacturing base for this and other pharmaceutical intermediates. Partnering with a reputable Chinese supplier can offer advantages in terms of both cost and accessibility. When evaluating suppliers, it is important to inquire about their production capacity, quality control measures, and ability to provide consistent supply. For those seeking to buy this intermediate for research or commercial purposes, understanding the specifications and requesting a quote from a trusted manufacturer is the first step towards a successful procurement.

The role of Rosuvastatin Methyl Ester underscores the importance of high-quality intermediates in bringing effective and safe medications to market. Its consistent availability and purity are fundamental for the pharmaceutical industry's ongoing efforts to combat cardiovascular diseases.