In the intricate world of chemical synthesis, particularly in sectors like pharmaceuticals and advanced materials, the stereochemical properties of intermediate compounds are often as important as their basic chemical structure. Specific rotation, a measure of how a chiral compound rotates plane-polarized light, is a critical parameter that directly indicates the enantiomeric purity of a sample. For R&D scientists and procurement professionals, understanding and verifying this specification is key when sourcing materials like (S)-1-N-Boc-2-Methylpiperazine (CAS 169447-70-5).

(S)-1-N-Boc-2-Methylpiperazine, a vital chiral building block, possesses a specific rotation of +68.5° in chloroform. This value is not merely a technical detail; it serves as a direct confirmation of the compound's enantiomeric excess (ee). In pharmaceutical synthesis, where the biological activity of a drug is often dictated by its specific three-dimensional structure, even minor variations in enantiomeric purity can lead to significant differences in efficacy, safety, or metabolic pathways. Therefore, when a buyer seeks to buy (S)-1-N-Boc-2-Methylpiperazine, they are not just looking for the chemical formula C10H20N2O2, but for a precise stereochemical configuration confirmed by this optical property.

When engaging with a potential supplier, such as a manufacturer in China, it is crucial to ensure they provide detailed product specifications that include the specific rotation. A reputable supplier will have robust quality control measures in place, including the necessary instrumentation to accurately measure this parameter. They should also be able to supply a Certificate of Analysis (COA) that clearly states the measured specific rotation for each batch. This verification process is essential for R&D scientists who need to ensure the reproducibility of their synthetic processes. For procurement managers, verifying this detail ensures that the product purchased aligns with the project’s stringent requirements, preventing costly downstream issues.

Beyond the specific rotation, other factors contribute to a reliable sourcing partnership. These include the overall purity of the intermediate (e.g., 98%), its physical form (white powder), melting point (34-36°C), production capacity, and export experience. Buyers often inquire about (S)-1-N-Boc-2-Methylpiperazine price to compare offerings, but the assurance of correct stereochemistry should never be compromised for cost savings. Companies that have a proven track record in supplying similar high-specification chiral intermediates are more likely to meet these demands. Therefore, when you need to purchase CAS 169447-70-5, look for suppliers who emphasize and can reliably demonstrate the specific rotation of their products.

In essence, specific rotation is a critical, often overlooked, specification for chiral chemical intermediates. By understanding its importance and diligently verifying it with suppliers, R&D professionals and procurement managers can significantly enhance the quality and predictability of their synthetic endeavors. Choosing partners who prioritize stereochemical accuracy ensures the successful development and manufacturing of advanced chemical products.