In the highly specialized field of pharmaceutical chemistry, certain molecules serve as foundational elements for life-saving treatments. (S)-2-hydroxybutanoic acid, identified by CAS 3347-90-8, is one such critical compound. Primarily recognized for its indispensable role as an intermediate in the synthesis of Idelalisib, a targeted cancer therapy, this chiral alpha-hydroxy acid is a cornerstone of modern drug production. Its meticulous manufacturing and precise specifications are vital for the pharmaceutical industry.

The chemical identity of this compound is precise: (2S)-2-hydroxybutanoic acid. Its molecular formula, C4H8O3, and molecular weight of 104.104, define its fundamental structure. Manufacturers aim for a high assay of ≥98.0%, ensuring that the material is pure and free from significant contaminants that could compromise downstream synthesis. Physically, it is typically presented as an off-white to light yellow crystalline powder, a form that is stable and manageable for industrial processes. The melting point, ranging from 50-54°C, further contributes to its ease of handling. When companies look to buy (S)-2-hydroxybutanoic acid, these specifications are primary considerations.

The most prominent application for (S)-2-hydroxybutanoic acid is its use as a key intermediate in the synthesis of Idelalisib. Idelalisib targets the phosphoinositide 3-kinase delta (PI3Kδ) pathway, which is implicated in the progression of certain B-cell leukemias and lymphomas. The therapeutic efficacy of Idelalisib is critically dependent on the correct stereochemistry, making the use of the (S)-enantiomer of 2-hydroxybutanoic acid non-negotiable. This demand places a significant emphasis on S-2-hydroxybutanoic acid manufacturers to ensure consistent production of enantiomerically pure material. The price of (S)-2-hydroxybutanoic acid can fluctuate, but the quality assurance provided by reputable suppliers is paramount.

Beyond its primary role in Idelalisib production, (S)-2-hydroxybutanoic acid also holds promise as a versatile chiral building block in other areas of organic synthesis. Its hydroxyl and carboxyl functional groups allow for a variety of chemical reactions, making it adaptable for developing new pharmaceutical candidates or specialty chemicals. For researchers and chemical engineers, sourcing this specific chiral intermediate enables the creation of complex molecular architectures with controlled stereochemistry. The common packaging of 25 kg drums facilitates its integration into various scales of production, from research laboratories to large-scale manufacturing facilities.

In conclusion, (S)-2-hydroxybutanoic acid is a vital component within the pharmaceutical supply chain. Its reliable synthesis, adherence to strict quality standards, and crucial application in Idelalisib manufacturing underscore its importance. As a versatile chiral building block, its significance is poised to grow as pharmaceutical innovation continues.