Sartan Synthesis: The Role of 4'-Bromomethyl-2-cyanobiphenyl
In the intricate world of pharmaceutical manufacturing, the selection of high-quality intermediates is paramount to producing effective and safe medications. Among these critical compounds, 4'-Bromomethyl-2-cyanobiphenyl stands out as a key building block, particularly in the synthesis of the widely used 'sartan' class of drugs. As a leading supplier of pharmaceutical intermediates, NINGBO INNO PHARMCHEM CO.,LTD. understands the significance of this chemical for R&D scientists and procurement managers worldwide.
The 'sartan' drugs, such as losartan, valsartan, and telmisartan, are primarily prescribed for managing hypertension and heart failure. Their efficacy relies heavily on precise molecular structures, which are meticulously constructed through multi-step organic synthesis. 4'-Bromomethyl-2-cyanobiphenyl, with its unique biphenyl structure and reactive functional groups, serves as a crucial precursor in many of these synthetic pathways. Its CAS number, 114772-54-2, is recognized for its role in creating active pharmaceutical ingredients (APIs) like azilsartan ester and temisartan.
For researchers and manufacturers seeking to buy this vital intermediate, understanding its properties is essential. Typically supplied as a white to almost white powder to crystal, 4'-Bromomethyl-2-cyanobiphenyl boasts a high purity, often exceeding 98.0% by GC. This purity level is non-negotiable in pharmaceutical synthesis to prevent side reactions and ensure the final API meets stringent quality standards. When sourcing from a reputable manufacturer in China, such as NINGBO INNO PHARMCHEM, you can be assured of consistent quality and reliable supply, crucial for uninterrupted production cycles.
The applications of 4'-Bromomethyl-2-cyanobiphenyl extend beyond its direct incorporation into APIs. It is also utilized in the determination of potential genotoxic impurities in drug substances, acting as a critical analytical standard. This dual role underscores its importance in the entire drug lifecycle, from initial synthesis to final quality control. For any procurement manager or R&D chemist in the pharmaceutical sector, securing a dependable source for this intermediate is a strategic imperative.
When considering a purchase, factors like price, packaging, and lead times are important. NINGBO INNO PHARMCHEM is committed to providing competitive pricing for 4'-Bromomethyl-2-cyanobiphenyl, making advanced pharmaceutical synthesis more accessible. We cater to various order sizes, from R&D samples to bulk industrial quantities, ensuring that whether you need a small amount for initial research or large volumes for commercial production, your needs are met. We encourage you to reach out to our sales team for a quote and to discuss your specific requirements for this key pharmaceutical intermediate.
Perspectives & Insights
Nano Explorer 01
“Among these critical compounds, 4'-Bromomethyl-2-cyanobiphenyl stands out as a key building block, particularly in the synthesis of the widely used 'sartan' class of drugs.”
Data Catalyst One
“understands the significance of this chemical for R&D scientists and procurement managers worldwide.”
Chem Thinker Labs
“The 'sartan' drugs, such as losartan, valsartan, and telmisartan, are primarily prescribed for managing hypertension and heart failure.”