Nicotinamide Riboside Chloride (NRCl), identified by CAS number 23111-00-4, is a compound increasingly sought after for its role as a potent NAD+ precursor. The ability to synthesize this molecule efficiently and at scale is a significant challenge and a core competency for chemical manufacturers. Understanding the synthesis pathways, particularly those that are scalable and yield high-purity products, is crucial for suppliers and buyers alike.

Research into NRCl often highlights the synthesis of its reduced form, 1,4-dihydronicotinamide riboside (NRH), from NRCl using reducing agents like sodium dithionate. Studies detail that while solid-phase synthesis or reactions under aerobic conditions may not be efficient, anaerobic reduction in an aqueous solution, carefully controlled for pH (around 8.1), can yield significant amounts of NRH. This process often involves meticulous purification techniques, such as column chromatography using a mixture of basic alumina and silica, to achieve purities upwards of 96%.

For a manufacturer, the transition from laboratory-scale synthesis to industrial production requires optimizing reaction parameters to maintain yield and purity while ensuring cost-effectiveness. Factors such as the choice of reducing agent, buffer systems, reaction temperature, and atmosphere are critical. The goal is to minimize side reactions, like the hydrolysis of NRCl or NRH, which can lead to impurities such as nicotinamide (NA) or dihydronicotinamide (DHNA).

When seeking to buy Nicotinamide Riboside Chloride, engaging with a supplier that has mastered these complex synthesis and purification processes is vital. Our expertise as a manufacturer in China allows us to offer NRCl that meets stringent quality standards. We focus on scalable methods that ensure a consistent supply of this valuable chemical intermediate. The stability studies also inform our manufacturing and packaging processes, ensuring that the product reaches our clients in optimal condition, ready for their intended applications, whether in research or for commercial product development.

By understanding the intricacies of NRCl synthesis, we at NINGBO INNO PHARMCHEM CO.,LTD. are better positioned to serve the market. We invite you to explore how our manufacturing capabilities can support your procurement needs for high-quality Nicotinamide Riboside Chloride.