Understanding the fundamental chemistry of key intermediates is essential for any professional involved in chemical synthesis or pharmaceutical development. 2H-1,2,4-Triazole-3-carboxamide (CAS 3641-08-5) is one such compound, a heterocyclic molecule with a significant impact, particularly in the antiviral drug sector. As a manufacturer dedicated to advancing chemical science, we aim to provide insights into this versatile compound.

Chemical Structure and Properties

The core of 2H-1,2,4-Triazole-3-carboxamide is the 1,2,4-triazole ring, a five-membered heterocyclic aromatic ring containing three nitrogen atoms. Attached to this ring is a carboxamide group (-CONH2). This structure, represented by the molecular formula C3H4N4O and molecular weight of 112.09 g/mol, grants it unique reactivity and biological activity. It typically presents as a white to off-white solid with a high melting point of 315°C, indicative of its stable crystalline form. The purity, often exceeding 95% when sourced from reputable manufacturers, is critical for its intended applications.

Synthesis Routes and Manufacturing Excellence

The synthesis of 2H-1,2,4-Triazole-3-carboxamide involves several chemical steps, often starting from readily available precursors like oxamic hydrazide and ethyl formimidate hydrochloride. Manufacturers employ optimized reaction conditions, including controlled temperatures and catalysts, to achieve high yields and purity. For instance, a common method involves condensation, followed by ammonolysis and cyclization. The efficiency and scalability of these synthesis routes are key differentiators for chemical producers. As a manufacturer in China, we leverage advanced synthesis techniques to ensure consistent quality and a reliable supply for researchers and industries worldwide.

Applications: Beyond the Primary Use

While 2H-1,2,4-Triazole-3-carboxamide is most famously recognized as an intermediate in the synthesis of antiviral drugs like Ribavirin, its utility is broader. In organic synthesis, it serves as a valuable building block for creating more complex heterocyclic systems. Its potential applications are being explored in fields ranging from agrochemicals to material science. Researchers looking to buy this compound often seek it for its established role in medicinal chemistry research and its potential in novel compound discovery.

Furthermore, its role as a Ribavirin-related impurity makes it an essential reference standard for pharmaceutical quality control. Analytical laboratories rely on such standards to validate their testing methods, ensuring the safety and efficacy of the final drug product.

Partnering with a Trusted Supplier

For seamless research and production, procuring 2H-1,2,4-Triazole-3-carboxamide from a trusted supplier in China, such as NINGBO INNO PHARMCHEM CO.,LTD., is a strategic decision. We offer not only high-purity material but also ensure consistent availability and competitive pricing, supporting your projects from laboratory scale to industrial production. We are committed to providing the chemical community with the tools needed for groundbreaking discoveries.