The intricate pathways of cellular metabolism are central to understanding health and disease. 2-Deoxy-D-Glucose (2-DG), identified by CAS number 154-17-6, is a molecule that has garnered considerable scientific interest due to its specific interaction with these pathways. As a dedicated manufacturer and supplier of fine chemicals and pharmaceutical intermediates, we delve into the science behind 2-DG and its market relevance.

Understanding the Mechanism of Action

2-Deoxy-D-Glucose is structurally similar to glucose but lacks a hydroxyl group at the carbon-2 position. This subtle difference is key to its function. When introduced into a cell, 2-DG is recognized and transported into the cell by glucose transporters (GLUTs). Once inside, it is phosphorylated by hexokinase to form 2-deoxy-D-glucose-6-phosphate (2-DG-6-P).

However, unlike glucose-6-phosphate, 2-DG-6-P cannot be further metabolized by phosphoglucose isomerase, the enzyme that converts glucose-6-phosphate to fructose-6-phosphate in the glycolytic pathway. This blockage effectively:

  • Inhibits Glycolysis: It disrupts the primary route for cellular energy production, leading to a decrease in ATP levels.
  • Induces Cellular Stress: The resulting metabolic imbalance can trigger endoplasmic reticulum (ER) stress and activate pathways like autophagy.
  • Impairs Glucose Utilization: It serves as a tool to study the reliance of cells, particularly cancer cells, on glucose metabolism.

These properties make 2-DG a valuable research tool in fields such as cancer biology, metabolic syndrome research, and neuroscience. Its ability to modulate cellular energy pathways also positions it as a compound of interest in drug discovery efforts.

Why Choose a Dedicated Manufacturer for Your 2-DG Needs?

For researchers and industries looking to buy 2-deoxy-D-glucose, partnering with a reliable manufacturer is essential for consistent quality and supply. Our company, a prominent supplier in China, offers:

  • Guaranteed Purity: We ensure our 2-DG meets high purity standards (e.g., 97% Min.), crucial for accurate scientific results.
  • Manufacturing Expertise: Our advanced synthesis capabilities ensure a stable and high-quality product.
  • Competitive Pricing: We provide excellent value, allowing researchers and developers to procure this important chemical economically.
  • Reliable Supply: We maintain robust production capacities to meet the demands of our clients.

Understanding the scientific basis of 2-DG empowers researchers to utilize it effectively. As a trusted source, we are committed to providing the high-purity 2-deoxy-D-glucose needed to drive innovation. If you are seeking to purchase 2-DG and require pricing or further technical details, please contact our sales team. We are your dependable partner for chemical excellence.