The journey of a pharmaceutical compound from laboratory synthesis to therapeutic application is a testament to scientific innovation. 2'-Deoxyuridine (CAS 951-78-0) is a prime example, a deoxynucleoside whose scientific underpinnings are crucial for its role in modern medicine. Understanding its synthesis, chemical properties, and biological functions provides a clear picture of why it is an indispensable intermediate for anti-tumor and antiviral drug development. As a leading chemical manufacturer in China, we are deeply invested in the science behind the high-purity 2'-Deoxyuridine we supply to the global pharmaceutical and research communities.

Understanding 2'-Deoxyuridine: Structure and Properties

2'-Deoxyuridine is chemically defined as a pyrimidine 2'-deoxyribonucleoside, featuring a uracil base attached to a deoxyribose sugar. Its molecular formula is C9H12N2O5, with a molecular weight of approximately 228.20 g/mol. Typically appearing as a white crystalline powder, it possesses a melting point between 167-169°C. Its solubility in water (300 g/L at 20°C) and other solvents like DMSO and methanol contributes to its ease of use in various chemical reactions and biological assays. The compound is also sensitive to air, necessitating careful handling and storage, ideally under inert conditions at cool temperatures (0-6°C), to maintain its integrity and purity.

Synthesis Pathways and Quality Assurance

The synthesis of 2'-Deoxyuridine often involves complex organic chemistry routes, starting from precursor molecules. For instance, one method involves the preparation from a protected uridine derivative via chemical reduction and deprotection steps. Ensuring high purity, typically ≥99%, is a critical aspect of its manufacturing. This is achieved through rigorous purification techniques, such as chromatography, and strict quality control measures implemented throughout the production process. Adherence to pharmacopoeia standards (USP, BP, EP, FCC) and certifications like GMP SGS are hallmarks of reliable manufacturers, guaranteeing that the 2'-Deoxyuridine supplied is suitable for pharmaceutical applications. Companies looking to buy 2'-Deoxyuridine can be assured that reputable suppliers maintain these high standards.

Therapeutic Significance: Anti-Tumor and Antiviral Applications

The primary therapeutic significance of 2'-Deoxyuridine lies in its role as a precursor for potent drugs targeting cancer and viral infections. In anti-tumor drug synthesis, it is a key intermediate for compounds like FUDR, which inhibits DNA synthesis in rapidly dividing cancer cells. For antiviral therapies, it is utilized in the creation of drugs such as TIDUR and BrDUR, which interfere with viral replication. Its ability to be modified into analogues with enhanced antiviral or anti-cancer properties makes it a highly versatile building block in drug discovery and development. Researchers also leverage its properties as a biochemical reagent for studying DNA synthesis and metabolism, contributing to a deeper understanding of cellular processes.

Reliable Sourcing from China

As a manufacturer and supplier of 2'-Deoxyuridine (CAS 951-78-0) in China, we are committed to bridging the gap between scientific understanding and practical application. We ensure that our synthesis processes are robust and our quality assurance protocols are comprehensive, providing the pharmaceutical and research sectors with a reliable source of this vital compound. We invite all interested parties to inquire about our product specifications and partner with us for their high-purity 2'-Deoxyuridine needs, whether for bulk pharmaceutical production or critical scientific research.