The Science Behind Cilostazol: Role of 1-Cyclohexyl-5-(4-chlorobutyl)-1H-tetrazole
Cilostazol, a vital medication for managing intermittent claudication and improving peripheral circulation, owes much of its therapeutic efficacy to its intricate synthesis pathway. Central to this process is the intermediate 1-Cyclohexyl-5-(4-chlorobutyl)-1H-tetrazole, known by its CAS number 73963-42-5. This molecule acts as a foundational component, enabling the precise construction of Cilostazol's complex structure, which is crucial for its phosphodiesterase III A (PDE3A) inhibitory activity.
The scientific significance of 1-Cyclohexyl-5-(4-chlorobutyl)-1H-tetrazole lies in its specific chemical architecture. The presence of the tetrazole ring, a nitrogen-rich heterocycle, and the chlorobutyl side chain provides the necessary reactive sites for subsequent synthetic steps. These features are strategically exploited during the synthesis to form the quinolinone moiety and the cyclohexyl substituent characteristic of Cilostazol. The successful synthesis of this intermediate, often reported with high yields of around 93%, requires meticulous control over reaction parameters, including temperature, solvents, and reagent addition. This focus on precise chemical reactions ensures the production of a pure and potent drug.
For manufacturers in the pharmaceutical industry, securing a consistent supply of high-quality 1-Cyclohexyl-5-(4-chlorobutyl)-1H-tetrazole is a critical operational requirement. Companies specializing in fine chemicals and pharmaceutical intermediates, particularly those in China, are key players in this supply chain. They ensure that the intermediate meets exacting standards, typically boasting purity levels above 95%. Understanding the importance of chemical building blocks for drugs like this one is fundamental for drug discovery and development. It highlights how advanced chemical manufacturing, supported by reliable suppliers in China, directly contributes to the availability of essential medications that improve cardiovascular health and patient quality of life. The reliable sourcing of such critical intermediates is a cornerstone of modern pharmaceutical production.
The scientific significance of 1-Cyclohexyl-5-(4-chlorobutyl)-1H-tetrazole lies in its specific chemical architecture. The presence of the tetrazole ring, a nitrogen-rich heterocycle, and the chlorobutyl side chain provides the necessary reactive sites for subsequent synthetic steps. These features are strategically exploited during the synthesis to form the quinolinone moiety and the cyclohexyl substituent characteristic of Cilostazol. The successful synthesis of this intermediate, often reported with high yields of around 93%, requires meticulous control over reaction parameters, including temperature, solvents, and reagent addition. This focus on precise chemical reactions ensures the production of a pure and potent drug.
For manufacturers in the pharmaceutical industry, securing a consistent supply of high-quality 1-Cyclohexyl-5-(4-chlorobutyl)-1H-tetrazole is a critical operational requirement. Companies specializing in fine chemicals and pharmaceutical intermediates, particularly those in China, are key players in this supply chain. They ensure that the intermediate meets exacting standards, typically boasting purity levels above 95%. Understanding the importance of chemical building blocks for drugs like this one is fundamental for drug discovery and development. It highlights how advanced chemical manufacturing, supported by reliable suppliers in China, directly contributes to the availability of essential medications that improve cardiovascular health and patient quality of life. The reliable sourcing of such critical intermediates is a cornerstone of modern pharmaceutical production.
Perspectives & Insights
Quantum Pioneer 24
“Cilostazol, a vital medication for managing intermittent claudication and improving peripheral circulation, owes much of its therapeutic efficacy to its intricate synthesis pathway.”
Bio Explorer X
“Central to this process is the intermediate 1-Cyclohexyl-5-(4-chlorobutyl)-1H-tetrazole, known by its CAS number 73963-42-5.”
Nano Catalyst AI
“This molecule acts as a foundational component, enabling the precise construction of Cilostazol's complex structure, which is crucial for its phosphodiesterase III A (PDE3A) inhibitory activity.”