Understanding the fundamental properties and applications of key chemical compounds is essential for scientific progress. Fmoc-O-tert-butyl-L-threonine, identified by CAS number 71989-35-0, is one such compound that plays a significant role in modern organic synthesis, particularly in the realm of peptide chemistry and drug discovery.

Chemically, Fmoc-O-tert-butyl-L-threonine is an N-alpha-Fmoc protected amino acid with a tert-butyl ester protecting the side-chain hydroxyl group of L-threonine. Its molecular formula is C23H27NO5, and it typically presents as a white powder. This structure is meticulously designed to facilitate controlled peptide bond formation. The Fmoc group provides acid-labile protection for the alpha-amino group, allowing for selective removal under basic conditions, a cornerstone of Fmoc-based solid-phase peptide synthesis (SPPS). The tert-butyl group on the threonine side chain is stable to these basic conditions but can be readily cleaved by strong acids, offering orthogonality and preventing side reactions during peptide chain elongation.

The applications of Fmoc-O-tert-butyl-L-threonine are diverse, primarily centered around its utility as a building block. In peptide synthesis, it is used to incorporate threonine residues into peptides, which are vital for many biologically active molecules. These peptides can range from short therapeutic peptides to larger protein fragments, essential in drug development, diagnostics, and fundamental biochemical research. Its role extends to protein engineering, where modified amino acids like this can be used to create proteins with novel or enhanced properties.

Researchers seeking to buy this compound will find it available from specialized chemical suppliers. The choice of supplier is critical; a reputable manufacturer will provide detailed specifications, certificates of analysis, and ensure consistent product quality and purity. For instance, sourcing Fmoc-O-tert-butyl-L-threonine from a trusted manufacturer in China can offer cost advantages and reliable access to this crucial intermediate. It is important to compare prices and ensure that the product meets the required purity levels for your specific application, whether it's for laboratory-scale synthesis or larger production runs.

The scientific community's reliance on compounds like Fmoc-O-tert-butyl-L-threonine underscores the importance of chemical synthesis expertise and reliable sourcing. As a dedicated supplier, we are committed to providing researchers with access to high-quality intermediates like this, supporting innovation across various scientific disciplines. Please reach out to us for any inquiries regarding our products or to discuss your custom synthesis needs.