The Science Behind Integrin Antagonists: A Focus on Cilengitide
Integrins are a large family of cell surface receptors that play vital roles in cell-cell adhesion, cell-extracellular matrix interactions, and signal transduction. They are critical components in numerous biological processes, including cell growth, migration, and survival. Dysregulation of integrin function is often implicated in diseases such as cancer, making them attractive targets for therapeutic intervention. Integrin antagonists, such as Cilengitide Trifluoroacetate, are designed to block these aberrant functions.
Cilengitide Trifluoroacetate is a well-studied integrin antagonist that exhibits high affinity for the αvβ3 and αvβ5 integrins. These specific integrins are frequently overexpressed in various tumor types and are involved in key cancer-related processes like angiogenesis, invasion, and metastasis. By binding to these integrins, Cilengitide effectively inhibits their signaling capabilities, thereby impeding tumor growth and progression.
The mechanism of action involves Cilengitide mimicking the natural ligands of these integrins, particularly the RGD (arginine-glycine-aspartic acid) sequence. This molecular mimicry allows Cilengitide to occupy the ligand-binding site on the integrin, preventing the binding of endogenous matrix proteins like vitronectin and fibronectin. This blockade disrupts downstream signaling pathways, including those involving focal adhesion kinase (FAK) and Akt, which are crucial for cell survival and proliferation. Consequently, Cilengitide can induce apoptosis and inhibit the formation of new blood vessels essential for tumor sustenance.
The scientific literature extensively documents the in vitro and in vivo effects of Cilengitide, underscoring its potential in cancer research and therapy development. Its role as a pharmaceutical intermediate means that researchers worldwide rely on its availability for studies aimed at understanding disease mechanisms and discovering new treatments. As a dedicated supplier, we ensure that high-quality Cilengitide Trifluoroacetate is accessible to the research community, supporting critical scientific investigations into integrin biology and its therapeutic implications.
Cilengitide Trifluoroacetate is a well-studied integrin antagonist that exhibits high affinity for the αvβ3 and αvβ5 integrins. These specific integrins are frequently overexpressed in various tumor types and are involved in key cancer-related processes like angiogenesis, invasion, and metastasis. By binding to these integrins, Cilengitide effectively inhibits their signaling capabilities, thereby impeding tumor growth and progression.
The mechanism of action involves Cilengitide mimicking the natural ligands of these integrins, particularly the RGD (arginine-glycine-aspartic acid) sequence. This molecular mimicry allows Cilengitide to occupy the ligand-binding site on the integrin, preventing the binding of endogenous matrix proteins like vitronectin and fibronectin. This blockade disrupts downstream signaling pathways, including those involving focal adhesion kinase (FAK) and Akt, which are crucial for cell survival and proliferation. Consequently, Cilengitide can induce apoptosis and inhibit the formation of new blood vessels essential for tumor sustenance.
The scientific literature extensively documents the in vitro and in vivo effects of Cilengitide, underscoring its potential in cancer research and therapy development. Its role as a pharmaceutical intermediate means that researchers worldwide rely on its availability for studies aimed at understanding disease mechanisms and discovering new treatments. As a dedicated supplier, we ensure that high-quality Cilengitide Trifluoroacetate is accessible to the research community, supporting critical scientific investigations into integrin biology and its therapeutic implications.
Perspectives & Insights
Nano Explorer 01
“Integrins are a large family of cell surface receptors that play vital roles in cell-cell adhesion, cell-extracellular matrix interactions, and signal transduction.”
Data Catalyst One
“They are critical components in numerous biological processes, including cell growth, migration, and survival.”
Chem Thinker Labs
“Dysregulation of integrin function is often implicated in diseases such as cancer, making them attractive targets for therapeutic intervention.”