For researchers and development professionals in the chemical and pharmaceutical industries, understanding the precise properties and applications of key compounds is vital. Nalpha-Fmoc-L-lysine Hydrochloride (CAS: 139262-23-0) is a compound that exemplifies this necessity, serving as a critical intermediate and a valuable tool in various scientific endeavors. This article aims to provide an in-depth look at its scientific characteristics and offers guidance for R&D professionals seeking to buy this essential material from reliable suppliers.

Chemical Identity and Properties

Nalpha-Fmoc-L-lysine Hydrochloride is characterized by its molecular formula C21H25ClN2O4 and a molecular weight of approximately 404.89 g/mol. Typically appearing as a white powder, it exhibits solubility in dimethylformamide (DMF), a common solvent in organic synthesis. The presence of the N-alpha Fmoc protecting group ensures that the alpha-amino group of lysine is shielded during synthesis, preventing unwanted reactions. This protection is crucial in multistep syntheses, particularly in peptide chemistry, where controlled deprotection and functionalization are paramount. The hydrochloride salt form contributes to its stability and ease of handling.

Key Applications in Research and Development

The utility of Nalpha-Fmoc-L-lysine Hydrochloride spans several critical R&D areas. Primarily, it functions as a vital pharmaceutical intermediate. Its incorporation into synthetic pathways allows for the creation of complex molecules, including Active Pharmaceutical Ingredients (APIs) and peptide-based drugs. The lysine side chain offers an additional reactive site, enabling researchers to conjugate the molecule with other entities, such as fluorescent dyes for diagnostic probes or cytotoxic agents for targeted drug delivery systems. In biochemical research, it is specifically used to synthesize fluorescently labeled lysine derivatives that act as tools for detecting protease cleavage, offering insights into cellular processes and enzyme activity.

Sourcing Considerations for R&D Professionals

When sourcing Nalpha-Fmoc-L-lysine Hydrochloride for research and development, several factors must be prioritized. Purity is paramount; a minimum purity of 98% (as determined by HPLC) is typically required to ensure reliable experimental outcomes and avoid misleading results. Consistency between batches is also critical for reproducible research. Prospective buyers should seek out manufacturers and suppliers who provide detailed Certificates of Analysis (CoA) and have established quality control procedures. For R&D teams, identifying a trustworthy supplier, especially one that can provide timely delivery and technical support, is as important as the product's intrinsic quality. We encourage you to contact us to obtain a quote and learn more about our commitment to supplying high-quality Nalpha-Fmoc-L-lysine Hydrochloride for your critical R&D projects.