In the dynamic landscape of pharmaceutical research, understanding the fundamental properties of chemical intermediates is crucial for innovation. Netarsudil Dimesylate, identified by its CAS number 1422144-42-0, is one such compound that plays a pivotal role in advancing drug development, particularly in the ophthalmic sector. This article explores the science behind Netarsudil Dimesylate, highlighting its chemical characteristics and its significance as a pharmaceutical intermediate.

Netarsudil Dimesylate is chemically described as (S)-4-(3-Amino-1-(isoquinolin-6-ylamino)-1-oxopropan-2-yl)benzyl 2,4-dimethylbenzoate dimethanesulfonate. Its molecular formula is C28H27N3O3 with two molecules of methanesulfonate, giving a molecular weight of approximately 645.74 g/mol. As a white to off-white powder, its physical form is consistent with many high-purity APIs and intermediates. The compound's primary scientific interest lies in its potent inhibition of Rho-associated protein kinases (ROCK), specifically ROCK1 and ROCK2, with very low Ki values reported (around 1 nM). This potent inhibitory activity is the basis for its therapeutic potential.

The scientific community leverages Netarsudil Dimesylate for various research applications. Its ability to disrupt actin stress fibers and focal adhesions in cells, and block profibrotic effects, makes it invaluable for studying cellular mechanics and signaling pathways. In ophthalmology, its application in reducing intraocular pressure (IOP) in preclinical models has been well-documented, suggesting its utility in developing new treatments for conditions like glaucoma. Researchers often purchase Netarsudil Dimesylate to investigate these mechanisms further, aiming to optimize dosage, delivery methods, and therapeutic outcomes.

For pharmaceutical companies and research institutions, securing a reliable supply of this intermediate is essential. Manufacturers specializing in fine chemicals and APIs ensure that Netarsudil Dimesylate is produced to exacting standards. When you buy Netarsudil Dimesylate from a reputable supplier, you are assured of its quality and the accuracy of the scientific data accompanying it. This enables seamless integration into complex research workflows, from cell culture studies to animal model experiments.

The continuous development in pharmaceutical science relies on the availability of well-characterized chemical entities. Netarsudil Dimesylate exemplifies such a compound, offering a scientifically robust foundation for therapeutic innovation. We, as a dedicated manufacturer and supplier, are committed to providing researchers with this critical intermediate, ensuring high purity and consistent quality. We encourage inquiries from scientists and procurement managers seeking this compound to advance their research and development projects, supporting the creation of next-generation treatments.