The exploration of natural compounds for their therapeutic potential is a cornerstone of modern pharmaceutical research. Orientin (CAS 28608-75-5), a prominent flavonoid glycoside, has demonstrated significant antioxidant and anti-inflammatory properties, making it a subject of intense scientific investigation. Understanding the underlying mechanisms of these actions is key to unlocking its full potential in drug development.

As an antioxidant, Orientin effectively scavenges reactive oxygen species (ROS) and mitigates oxidative stress, a critical factor in the pathogenesis of numerous diseases, including cardiovascular disorders, neurodegenerative conditions, and aging. Its ability to neutralize free radicals like DPPH radicals with a notable IC50 value highlights its potency in protecting cellular components from oxidative damage. This makes it a valuable compound for researchers investigating novel antioxidant therapies.

Beyond its antioxidant capabilities, Orientin also exhibits significant anti-inflammatory effects. Scientific literature details its capacity to inhibit key inflammatory pathways. For instance, it has been shown to decrease the expression of toll-like receptor 4 (TLR4), phosphorylated p38, and NF-κB, while simultaneously reducing the production of pro-inflammatory cytokines such as TNF-α and IL-6. These effects were observed in a dose-dependent manner in cellular models, underscoring its role in modulating inflammatory responses.

Furthermore, studies have indicated that Orientin can prolong survival in animal models of sepsis, a severe inflammatory condition. This in vivo efficacy, coupled with its demonstrated cellular mechanisms, positions Orientin as a promising candidate for therapeutic intervention in inflammatory diseases. For researchers and pharmaceutical manufacturers looking to leverage these properties, sourcing high-quality Orientin is essential.

As a leading supplier of Orientin (CAS 28608-75-5) from China, we provide researchers with a reliable source of this potent natural compound. Our commitment to high purity ensures that the scientific integrity of your studies is maintained. We encourage you to explore the scientific literature further and consider partnering with us to buy Orientin for your advanced research in antioxidant and anti-inflammatory applications. Understanding these mechanisms will guide your formulation and therapeutic development.