At the intersection of chemistry and biology lies a fascinating class of molecules that govern a vast array of physiological processes. Among these, 2-Acetyl-1-O-hexadecyl-3-phosphatidylcholine, commonly known as PAF, stands out for its potent biological activities. Understanding its chemical structure and properties is key to appreciating its profound impact on cellular signaling, inflammation, and more. NINGBO INNO PHARMCHEM CO.,LTD., as a dedicated manufacturer and supplier of high-purity biochemicals, is committed to providing researchers with this essential compound (CAS 77286-68-1) to facilitate their scientific endeavors.

Chemically, PAF is an ether phospholipid. Its structure features a glycerol backbone esterified with a hexadecyl (C16) alkyl chain at the sn-1 position, an acetyl group at the sn-2 position, and a phosphorylcholine head group at the sn-3 position. This specific arrangement of functional groups imparts its unique characteristics. The long hexadecyl chain provides lipophilicity, allowing it to integrate into cell membranes, while the polar phosphorylcholine head group contributes to its amphipathic nature.

The molecular weight of PAF is approximately 523.69 g/mol, and it typically presents as a white solid. This physical form is advantageous for handling and storage, contributing to its stability. Its solubility characteristics are also important for experimental use; it is generally soluble in ethanol and other organic solvents, and can be dispersed in aqueous solutions, often with the aid of sonication or co-solvents.

Biologically, PAF is renowned for its potent signaling capabilities, acting as a mediator in a wide range of cellular responses. Even at picomolar to nanomolar concentrations, it can trigger significant physiological events. These include:

  • Platelet Aggregation: Crucial for blood clotting, but also implicated in thrombotic diseases.
  • Inflammation: A key player in recruiting immune cells and amplifying inflammatory cascades.
  • Vascular Effects: Influencing blood pressure and vascular permeability.
  • Bronchoconstriction: Contributing to airway narrowing, relevant in asthma.
  • Other Cellular Responses: Involved in processes like glycogenesis and cellular breakdown.

The diverse biological actions of PAF make it an indispensable research tool for scientists investigating these fundamental processes. For professionals looking to buy PAF lipid, NINGBO INNO PHARMCHEM CO.,LTD. offers a reliable source. Our commitment as a supplier in China ensures high purity (typically >97%) and consistent quality, enabling accurate and reproducible research.

We understand that procuring research-grade chemicals requires trust and confidence in the supplier. As a leading manufacturer, we ensure our products meet the highest standards. We invite researchers and procurement specialists to contact us for competitive PAF lipid prices and to learn more about our comprehensive product offerings. Explore the scientific potential with high-quality 2-Acetyl-1-O-hexadecyl-3-phosphatidylcholine from NINGBO INNO PHARMCHEM CO.,LTD.