The creation of modern pharmaceuticals is a testament to the power of organic chemistry and meticulous process development. At the heart of this process lie pharmaceutical intermediates – precisely synthesized molecules that serve as critical building blocks for Active Pharmaceutical Ingredients (APIs). Today, we explore the fascinating chemistry behind pyrazolo[3,4-b]pyridine derivatives, focusing on 5-Fluoro-1-(2-fluorobenzyl)-3-iodo-1H-pyrazolo[3,4-b]pyridine (CAS: 1350653-24-5), a key intermediate used in the synthesis of important cardiovascular drugs like Vericiguat.

As a specialized pharmaceutical intermediate manufacturer and supplier, understanding the intricate synthesis pathways of these compounds is fundamental to our operations. The pyrazolo[3,4-b]pyridine scaffold itself is a bicyclic aromatic heterocycle, combining a pyrazole ring fused with a pyridine ring. Its structural versatility allows for diverse functionalization, making it a valuable motif in medicinal chemistry.

Key Features of 5-Fluoro-1-(2-fluorobenzyl)-3-iodo-1H-pyrazolo[3,4-b]pyridine

The specific structure of 5-Fluoro-1-(2-fluorobenzyl)-3-iodo-1H-pyrazolo[3,4-b]pyridine is designed for specific roles in subsequent synthetic steps:

  • Fluorine Substituents: The presence of fluorine atoms often enhances metabolic stability and bioavailability in drug molecules.
  • Iodo Group: The iodine atom is a good leaving group, making it highly reactive in various coupling reactions, such as Suzuki or Sonogashira couplings, which are common in API synthesis.
  • 2-Fluorobenzyl Group: This moiety contributes to the overall molecular structure and can influence the binding interactions of the final drug.

The synthesis of such a molecule involves multiple steps, often starting from simpler precursors and employing specific reagents and reaction conditions to achieve the desired regioselectivity and yield. For instance, the introduction of the iodo group typically requires specific iodination reagents, while the benzyl group is often attached via an alkylation reaction.

For pharmaceutical researchers and procurement specialists who need to buy 5-Fluoro-1-(2-fluorobenzyl)-3-iodo-1H-pyrazolo[3,4-b]pyridine intermediate, it is crucial to partner with a manufacturer who not only masters these synthesis routes but also ensures stringent quality control. We pride ourselves on our technical expertise in producing such complex intermediates. Our ability to provide reliable supplies of Vericiguat synthesis intermediates for sale, with guaranteed purity and competitive pharmaceutical intermediate price lists, makes us an ideal partner.

We invite you to explore the scientific depth behind our products. If your work involves APIs that utilize pyrazolo[3,4-b]pyridine scaffolds, or if you are looking for reliable CAS 1350653-24-5, connect with us. We are dedicated to advancing pharmaceutical science through the provision of high-quality chemical building blocks.