The concept of longevity, extending not just lifespan but also healthspan, is a growing area of scientific and public interest. At the cellular level, maintaining robust metabolic function and mitigating age-related damage are key. This is where the role of NAD+ and its downstream effector, SIRT1, becomes critical, and where NNMT inhibitors like 5-Amino-1MQ (CAS 42464-96-0) are showing significant promise.

NAD+ (Nicotinamide Adenine Dinucleotide) is a fundamental coenzyme found in all living cells. It plays a crucial role in energy metabolism, acting as a redox cofactor in cellular respiration. Beyond energy, NAD+ is also a substrate for enzymes involved in DNA repair, gene regulation, and cellular signaling – processes that are vital for maintaining cellular health and combating the effects of aging. Unfortunately, NAD+ levels naturally decline with age, contributing to various age-related dysfunctions.

Nicotinamide N-methyltransferase (NNMT) is an enzyme that catalyzes the methylation of nicotinamide, a precursor to NAD+. By doing so, NNMT effectively reduces the pool of available nicotinamide for NAD+ synthesis. This enzymatic activity makes NNMT a key regulator of cellular NAD+ levels. Inhibiting NNMT, therefore, offers a direct pathway to increasing NAD+ availability within cells.

This is precisely where 5-Amino-1MQ comes into play. As a potent NNMT inhibitor, it effectively blocks the enzyme’s methylating activity, leading to a significant increase in cellular NAD+ concentrations. This boost in NAD+ has far-reaching benefits, one of the most notable being the activation of Sirtuin 1 (SIRT1).

SIRT1 is a NAD+-dependent deacetylase enzyme that is often referred to as the 'longevity gene.' It is involved in a wide array of cellular processes that promote health and longevity, including DNA repair, stress resistance, metabolic regulation, and inflammation control. When NAD+ levels are high, SIRT1 is more active, conferring protective benefits against various age-related diseases such as cardiovascular disease, diabetes, and neurodegenerative disorders.

The connection is clear: by inhibiting NNMT, 5-Amino-1MQ indirectly activates SIRT1, thereby contributing to cellular resilience and potentially extending healthspan. For researchers and developers in the anti-aging and wellness sectors, understanding and utilizing compounds like 5-Amino-1MQ is key. NINGBO INNO PHARMCHEM CO.,LTD. is a leading supplier that can provide the high-purity 5-amino-1mq you need. We encourage you to inquire about purchasing our product to explore its potential in your applications.

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