For researchers and development professionals in the pharmaceutical and biotechnology sectors, sourcing high-quality chemical intermediates is paramount. Among these, 4-Phenylbenzamidine Hydrochloride (CAS: 111082-23-6) stands out due to its critical role as a serine protease inhibitor. Understanding its properties and where to procure it reliably is essential for project success. This article serves as a guide for procurement managers and R&D scientists looking to buy this vital compound.

Understanding 4-Phenylbenzamidine Hydrochloride

4-Phenylbenzamidine Hydrochloride, typically appearing as a white to off-white powder with a purity of 98% by HPLC, is a well-established inhibitor of serine proteases. These enzymes, including trypsin, plasmin, and thrombin, are involved in numerous biological processes, making them targets for therapeutic intervention and subjects of extensive research. The ability of 4-Phenylbenzamidine Hydrochloride to act as a reversible, competitive inhibitor makes it an indispensable tool in laboratories worldwide.

Key Applications in Research and Development

The utility of 4-Phenylbenzamidine Hydrochloride spans several critical areas:

  • Enzymology: Its primary function is inhibiting serine proteases, allowing researchers to study enzyme mechanisms, kinetics, and to prevent protein degradation during purification processes. This is crucial for obtaining stable protein samples for structural analysis or functional assays.
  • Drug Discovery: As a key intermediate, it is utilized in the synthesis of novel drug candidates aimed at treating diseases related to aberrant protease activity, such as thrombosis or inflammation. Its structure provides a valuable scaffold for medicinal chemists.
  • Biochemistry: In biochemical assays, its precise inhibitory action ensures reliable results, supporting the development of diagnostic tools and the validation of biological pathways.

Sourcing Strategies for Procurement Managers

When seeking to purchase 4-Phenylbenzamidine Hydrochloride, procurement managers should focus on:

  • Manufacturer Reputation: Prioritize suppliers with a proven track record in producing high-purity chemicals, especially those with manufacturing bases in regions known for chemical expertise, like China. A reliable manufacturer ensures consistent product quality and supply.
  • Purity and Specifications: Always verify that the product meets the required purity (e.g., 98% HPLC) and has comprehensive technical data available, including CAS number, appearance, and stability information.
  • Price and Bulk Discounts: Compare pricing from multiple reputable suppliers, paying attention to bulk purchase discounts. Obtaining a detailed quote from a trusted manufacturer can provide significant cost savings.
  • Supply Chain Reliability: Ensure the supplier has a robust supply chain and can meet your projected demand. Understanding lead times and potential disruptions is key for uninterrupted R&D or production.

For organizations that require a consistent and high-quality supply of 4-Phenylbenzamidine Hydrochloride, partnering with an experienced manufacturer in China offers significant advantages. These include competitive pricing, extensive production capabilities, and adherence to international quality standards. By carefully evaluating suppliers and understanding your specific needs, you can secure the essential reagents needed to drive your research and development forward.