In the dynamic field of drug discovery and development, the availability of versatile and high-purity chemical intermediates is fundamental. 2,4,6-Trimethylphenyl Isothiocyanate (CAS: 6095-82-5) is one such compound that plays a significant role as a building block in the synthesis of novel therapeutic agents. As a prominent manufacturer and supplier of this critical intermediate from China, we recognize its importance and are dedicated to providing researchers and pharmaceutical companies with a reliable source.

What is 2,4,6-Trimethylphenyl Isothiocyanate?

2,4,6-Trimethylphenyl Isothiocyanate is an organic compound characterized by its aromatic structure and the presence of a highly reactive isothiocyanate functional group (-N=C=S). Its molecular formula is C10H11NS, and it is known for its high purity, typically assaying at 99.0% or higher. The three methyl groups on the phenyl ring can influence the steric and electronic properties of molecules derived from it, offering unique advantages in medicinal chemistry design.

Key properties relevant to its use include:

  • Molecular Weight: 177.27 g/mol
  • Melting Point: 63-64°C
  • Boiling Point: 144-145°C/10mm
  • Application: Primarily as a pharmaceutical intermediate.

These specifications highlight its suitability for precise chemical reactions essential in drug synthesis.

Role in Drug Discovery and Development

The isothiocyanate group is a versatile synthon, readily reacting with nucleophiles such as amines, alcohols, and thiols. This reactivity makes 2,4,6-Trimethylphenyl Isothiocyanate invaluable in constructing complex molecular scaffolds that are common in pharmaceuticals. Specifically, it is used in:

  • Synthesis of Thioureas: Reaction with amines yields substituted thioureas, a structural motif found in many biologically active compounds, including potential anticancer agents, antivirals, and anti-inflammatory drugs.
  • Formation of Heterocycles: It can be incorporated into the synthesis of various nitrogen- and sulfur-containing heterocyclic ring systems, which are prevalent in drug molecules.
  • Fragment-Based Drug Design: As a well-defined chemical fragment, it can be used in fragment-based approaches to drug discovery, where smaller molecular pieces are gradually assembled to create potent drug candidates.

Sourcing Reliability: Why Choose Us?

For drug discovery programs and pharmaceutical manufacturers, a consistent and reliable supply of intermediates is crucial. We, as a leading China-based manufacturer and supplier of 2,4,6-Trimethylphenyl Isothiocyanate, offer:

  • High-Quality Product: Guaranteed purity of 99.0% minimum ensures the integrity of your research and development efforts.
  • Competitive Pricing: Direct manufacturing allows us to offer cost-effective solutions without compromising on quality.
  • Scalable Production: We can support projects from early-stage research with small quantities to large-scale commercial manufacturing needs.
  • Expert Support: Our team provides technical assistance and ensures all necessary documentation for compliance and usage.

If your drug discovery pipeline requires high-purity 2,4,6-Trimethylphenyl Isothiocyanate, we invite you to contact us to discuss your requirements. Partnering with a reliable manufacturer ensures that your supply chain remains robust, allowing you to focus on the critical task of bringing new medicines to market.