In the realm of organic chemistry and pharmaceutical manufacturing, certain molecules stand out due to their unique structural features and versatile applications. (S)-4-(4'-Nitrobenzyl)-1,3-oxazolidine-2-one (CAS: 139264-66-7) is one such compound, recognized for its crucial role as a chiral intermediate in the synthesis of advanced pharmaceutical agents. This article delves into its chemical significance, properties, and the importance of its procurement for research and development professionals.

Understanding (S)-4-(4'-Nitrobenzyl)-1,3-oxazolidine-2-one

This compound is characterized by its distinct molecular structure, which includes an oxazolidinone ring and a nitrobenzyl group. The designation '(S)' refers to its specific stereochemistry, indicating a particular spatial arrangement of atoms around a chiral center. This chirality is often critical for a molecule's biological activity, making enantiomerically pure intermediates like this one highly valuable in medicinal chemistry. Its molecular formula is C10H10N2O4, with a molecular weight of approximately 222.2 g/mol.

Key properties, as reported by manufacturers, often include:

  • Purity: Typically offered at purities of 95%min or higher, ensuring reliable performance in synthesis.
  • Stability: Stable under normal conditions, facilitating storage and handling.
  • Physical State: While specific physical appearance is not always detailed, similar compounds are often crystalline solids.

Applications in Pharmaceutical Synthesis

The primary significance of (S)-4-(4'-Nitrobenzyl)-1,3-oxazolidine-2-one lies in its utility as a building block for more complex pharmaceutical molecules. Its most recognized application is in the synthesis of serotonin agonists. These drugs are vital in treating conditions such as migraines, depression, and anxiety, by modulating serotonin levels in the brain. The precise chiral nature of the intermediate is indispensable for achieving the desired pharmacological effect and minimizing adverse reactions associated with inactive enantiomers.

Beyond serotonin agonists, this compound can be utilized in the broader field of medicinal chemistry for the development of novel drug candidates. Its oxazolidinone core is a known pharmacophore, and the nitrobenzyl substituent can be further modified or utilized in various synthetic pathways. Researchers looking to buy this intermediate for custom synthesis projects will find it an excellent starting material.

Procurement and Supplier Considerations

For professionals in the pharmaceutical industry, securing a reliable supply of (S)-4-(4'-Nitrobenzyl)-1,3-oxazolidine-2-one is paramount. When searching for a manufacturer or supplier, it is crucial to consider:

  • Purity and Quality Assurance: Always request a Certificate of Analysis (CoA) to confirm purity, CAS number, and other specifications.
  • Supplier Reputation: Partner with established chemical suppliers, especially those with a strong presence in China, known for competitive pricing and manufacturing capabilities.
  • Quantity and Pricing: Obtain quotations for the required quantities, whether for laboratory research or pilot-scale production. Understand that bulk purchases often come with better per-unit pricing.
  • Technical Support: A knowledgeable supplier can offer valuable insights into the product's handling and application.

In conclusion, (S)-4-(4'-Nitrobenzyl)-1,3-oxazolidine-2-one is a high-value chiral intermediate that plays a significant role in the development of essential medicines. Its chemical properties and established applications make it a sought-after compound for any R&D laboratory engaged in pharmaceutical synthesis. We are dedicated to supplying this vital intermediate with unwavering quality and reliability.