Sirolimus (Rapamycin), identified by CAS number 53123-88-9, is a potent pharmaceutical intermediate known for its immunosuppressive properties and its role as an mTOR inhibitor. For procurement professionals and researchers, understanding its typical dosage ranges and potential side effects is crucial when evaluating its use and sourcing the compound from reliable manufacturers.

Sirolimus (Rapamycin) Dosage Considerations
The dosage of Sirolimus (Rapamycin) varies significantly depending on its intended use and the patient's condition. In medical applications, such as preventing transplant rejection or treating lymphangioleiomyomatosis, dosages are carefully determined by healthcare professionals. For research purposes, it is typically used in in-vitro cell culture studies or animal models, where concentrations are adjusted based on experimental design and known cellular effects.

When you buy Sirolimus (Rapamycin) powder for research, consider that:

  • Concentration in Cell Culture: Sirolimus is often used at nanomolar (nM) to micromolar (µM) concentrations in cell culture to inhibit mTOR signaling effectively. Specific concentrations can vary based on cell type and the desired experimental outcome.
  • Animal Studies: Dosage in animal models is typically calculated based on body weight and is subject to rigorous ethical review.
  • Purity Matters: The purity of the Sirolimus (Rapamycin) purchased directly impacts the accuracy of dosage calculations and experimental results. Always ensure you are sourcing from a reputable Sirolimus (Rapamycin) manufacturer that guarantees high purity (e.g., 99%).

Understanding Potential Side Effects
Sirolimus is a powerful drug, and like many potent pharmaceuticals, it can have significant side effects. Awareness of these is important for anyone involved in its handling or research application. Common side effects reported in clinical settings include:

  • Metabolic Disturbances: Hypercholesterolemia, hypertriglyceridemia, and potential for new-onset diabetes or impaired glucose tolerance.
  • Hematological Changes: Anemia, thrombocytopenia, and leukopenia.
  • Immune System Effects: Increased susceptibility to infections due to immunosuppression.
  • Gastrointestinal Issues: Diarrhea, nausea, abdominal pain, and stomatitis.
  • Skin and Wound Healing: Acne, rash, and impaired wound healing.

While research applications may not directly involve patient administration, understanding these effects helps in designing safe experimental protocols and handling procedures.

Reliable Sourcing for Accurate Research
Procuring Sirolimus (Rapamycin) CAS 53123-88-9 from a trusted Sirolimus (Rapamycin) supplier China ensures you receive a product with consistent quality and purity. NINGBO INNO PHARMCHEM CO.,LTD. is committed to providing researchers and pharmaceutical companies with the reliable materials needed for accurate and effective work.