For researchers in biochemistry, molecular biology, and related fields, understanding the function and applications of key intermediates is fundamental. Sodium 3-Phosphoglycerate (CAS 17603-42-8) is one such compound, playing a pivotal role in fundamental metabolic pathways and serving as a valuable reagent in laboratory settings.

What is Sodium 3-Phosphoglycerate?

Sodium 3-Phosphoglycerate, often referred to as 3-PGA, is a biochemically significant molecule. It is a three-carbon compound that functions as a metabolic intermediate. Its chemical structure, characterized by a phosphate group attached to the third carbon of glycerate, makes it hydrophilic and soluble in water, facilitating its integration into biological systems and aqueous laboratory preparations. Typically appearing as a white crystalline powder, it is stable under appropriate storage conditions.

Key Metabolic Pathways: Glycolysis and the Calvin Cycle

The significance of 3-PGA lies in its central position within two critical energy-related metabolic pathways:

  • Glycolysis: In this process, glucose is broken down to produce ATP, the cell's primary energy currency. 3-PGA is formed from the splitting of fructose-1,6-bisphosphate and is subsequently converted into phosphoenolpyruvate, moving the pathway towards pyruvate formation.
  • Calvin Cycle: This is the light-independent phase of photosynthesis where carbon dioxide is fixed into organic compounds. In the Calvin cycle, an unstable six-carbon intermediate spontaneously splits into two molecules of 3-phosphoglycerate for every molecule of CO2 fixed. These molecules are then further processed to regenerate the starting compound, RuBP, and produce sugars.

Applications in Research and Pharmaceutical Development

Given its central role in cellular metabolism, Sodium 3-Phosphoglycerate is a valuable tool for researchers. It can be used to study enzyme kinetics, pathway flux, and the effects of various inhibitors or activators on these processes. Its commercial availability from reliable chemical manufacturers and suppliers allows researchers to easily source this compound for their experiments.

Beyond pure biochemical research, Sodium 3-Phosphoglycerate finds application in the pharmaceutical industry. It is used in the formulation of intravenous phosphorus supplements, addressing deficiencies that can arise in various clinical conditions. For professionals in this sector, understanding where to buy high-quality Sodium 3-Phosphoglycerate with guaranteed purity is crucial for developing effective therapeutic solutions.

Procuring Sodium 3-Phosphoglycerate for Your Lab

When sourcing Sodium 3-Phosphoglycerate for research or pharmaceutical development, it is imperative to partner with reputable suppliers. Look for manufacturers that provide clear specifications and reliable product data. Buying directly from a trusted chemical manufacturer ensures you receive a product with consistent purity, which is essential for accurate experimental results and safe pharmaceutical formulations. Consider your specific needs regarding quantity and purity when making your purchase decision.

In essence, Sodium 3-Phosphoglycerate is a fundamental biochemical intermediate with far-reaching implications in cellular energy and carbon fixation. Its dual utility in fundamental research and practical pharmaceutical applications underscores its importance in the scientific and industrial landscape.