For procurement managers and research scientists in the pharmaceutical industry, securing reliable sources for key chemical intermediates is paramount. 1-Chloro-3-iodobenzene, identified by its CAS number 625-99-0, stands out as a critical dual-halogenated aromatic compound with immense utility in advanced synthesis. Understanding its properties and how to procure it effectively is crucial for successful drug discovery and development.

Why 1-Chloro-3-iodobenzene is Indispensable

1-Chloro-3-iodobenzene is highly valued for its unique structure, featuring halogen atoms at the meta positions. This specific arrangement provides “orthogonal reactivity,” meaning the iodine and chlorine atoms can be selectively reacted in sequential synthetic steps. This is particularly advantageous in cross-coupling reactions, such as Suzuki couplings where the iodine can be activated first, followed by subsequent reactions at the chlorine site. This capability makes it an indispensable building block for complex pharmaceutical scaffolds, including those used in antiviral and anticancer agents.

Key Applications in Pharmaceutical Synthesis

The primary use of 1-Chloro-3-iodobenzene lies in its role as a pharmaceutical intermediate. Its ability to undergo controlled, stepwise functionalization allows for the precise construction of target molecules, minimizing unwanted by-products and optimizing yields. Beyond pharmaceuticals, it also finds applications in the synthesis of liquid crystals and as a component in organic electronics, such as OLED host materials. This versatility underscores its importance across various high-tech chemical sectors.

Procurement Considerations for B2B Buyers

When looking to buy 1-Chloro-3-iodobenzene, B2B buyers should prioritize sourcing from reputable manufacturers and suppliers, particularly those based in China, known for their competitive pricing and extensive production capabilities. Key factors to consider include:

  • Purity: High purity, typically 98% or greater, is essential for pharmaceutical applications to ensure reaction specificity and product quality. Always request a Certificate of Analysis (COA).
  • CAS Number: Confirming the CAS number 625-99-0 ensures you are acquiring the correct isomer.
  • Supply Stability: Partnering with a manufacturer that has consistent production capacity and a robust supply chain is vital to avoid disruptions in your R&D or manufacturing schedules.
  • Pricing and MOQs: Competitive pricing and flexible Minimum Order Quantities (MOQs) are important for managing project budgets. Requesting a quote is the first step.
  • Technical Support: A knowledgeable supplier can offer insights into handling, storage, and optimal use of the chemical.

As a leading chemical supplier in China, we specialize in providing high-quality 1-Chloro-3-iodobenzene to the global market. We understand the stringent requirements of the pharmaceutical industry and are committed to delivering products that meet rigorous quality standards. Our aim is to be your trusted partner, facilitating your access to essential intermediates like 1-Chloro-3-iodobenzene and supporting your innovation journey.