For procurement managers and R&D scientists in the chemical, pharmaceutical, and agrochemical sectors, identifying reliable sources for critical intermediates is paramount. One such vital compound is 2,5-Difluorotoluene (CAS 452-67-5). This article aims to provide a comprehensive overview for those looking to buy this essential building block, focusing on its properties, applications, and how to best secure a consistent supply from reputable manufacturers, especially those based in China.

Understanding 2,5-Difluorotoluene: Properties and Specifications

2,5-Difluorotoluene, also known by its synonym 1,4-Difluoro-2-methylbenzene, is characterized by its molecular formula C7H6F2 and a molecular weight of 128.12. Typically supplied as a colorless to light yellow transparent liquid, its key physical properties include a boiling point of 117°C at 775 mmHg and a melting point of -35°C. The compound is classified as a flammable liquid (Flash Point: 12°C, UN Number: UN1993, Class 3), necessitating careful handling and storage protocols, often in a cool, well-ventilated area. For industrial applications, purity is a critical factor, and reputable suppliers commonly offer 2,5-Difluorotoluene with a purity of ≥98%, ensuring its suitability for complex synthesis routes. The water content is typically kept at ≤0.5%.

Applications: Where is 2,5-Difluorotoluene Used?

The versatility of 2,5-Difluorotoluene makes it a sought-after intermediate across several industries:

  • Pharmaceutical Intermediates: It serves as a foundational building block in the synthesis of various Active Pharmaceutical Ingredients (APIs). Its unique fluorinated structure can enhance the efficacy, metabolic stability, and bioavailability of drug candidates. Researchers often seek this compound when developing novel treatments for diverse therapeutic areas.
  • Agrochemical Intermediates: In the agricultural sector, 2,5-Difluorotoluene is crucial for the production of advanced pesticides, herbicides, and fungicides. These agrochemicals are designed for greater efficacy and improved environmental profiles, contributing to sustainable agricultural practices.
  • Organic Synthesis: Beyond pharmaceuticals and agrochemicals, this compound is widely used in general organic synthesis for creating complex molecules and specialty chemicals. Its reactivity allows for specific substitution reactions, opening pathways for materials science and advanced chemical R&D.

Sourcing 2,5-Difluorotoluene: Key Considerations for Buyers

When looking to purchase 2,5-Difluorotoluene, several factors are crucial for making an informed decision:

  • Purity and Quality: Always verify the product's specifications, especially purity (≥98% is standard) and any critical impurities. Requesting a Certificate of Analysis (CoA) is standard practice.
  • Supplier Reliability: Partner with established manufacturers and suppliers who have a proven track record of quality, consistency, and timely delivery. Many global companies source this intermediate from China due to its robust chemical manufacturing capabilities.
  • Pricing and Bulk Orders: Obtain quotes for both small R&D quantities and larger industrial volumes. Understanding the pricing structure based on order size is essential for budgeting. A reliable manufacturer in China can offer competitive pricing for bulk purchases.
  • Safety Data Sheets (SDS): Ensure you have access to the SDS for safe handling, storage, and emergency procedures.
  • Certifications: For regulated industries like pharmaceuticals, inquire about any relevant certifications the supplier may hold.

For businesses requiring high-quality 2,5-Difluorotoluene (CAS 452-67-5), identifying a dependable manufacturer and supplier is key to success. By understanding its properties and applications, and by diligently vetting potential partners, procurement managers can secure this vital chemical intermediate efficiently and cost-effectively. If you are looking to buy 2,5-Difluorotoluene from a trusted manufacturer in China, exploring options from established suppliers is a strategic first step.