In the complex landscape of pharmaceutical manufacturing, the consistent availability of high-quality intermediates is paramount. Among these critical building blocks is 2,6-Dichloropurine (CAS 5451-40-1), a compound indispensable for the synthesis of essential drugs, most notably Clofarabine. For procurement managers and research scientists, understanding the sourcing of such intermediates is key to ensuring production efficiency and drug efficacy.

What is 2,6-Dichloropurine?

2,6-Dichloropurine is a heterocyclic organic compound belonging to the purine family. Its chemical structure, C5H2Cl2N4, features two chlorine atoms at the 2 and 6 positions of the purine ring. Typically appearing as an off-white to light yellow crystalline powder, it has a melting point in the range of 185-195°C. Its high purity, often exceeding 99.0% as verified by HPLC, is a critical specification for pharmaceutical applications, as it directly impacts the quality and yield of the final active pharmaceutical ingredient (API).

The Role in Clofarabine Synthesis

The primary significance of 2,6-Dichloropurine lies in its role as a key intermediate in the synthesis of Clofarabine. Clofarabine is a purine nucleoside antimetabolite used in the treatment of certain types of acute lymphoblastic leukemia (ALL) and other cancers. The precise and reliable synthesis of Clofarabine heavily relies on the consistent quality and availability of its precursor, 2,6-Dichloropurine. Any impurity or inconsistency in the intermediate can lead to significant complications in the downstream production process, affecting the final drug's safety and efficacy.

Why Sourcing Matters: Manufacturer and Supplier Considerations

For businesses requiring 2,6-Dichloropurine, identifying a reliable manufacturer and supplier is crucial. When evaluating potential suppliers, several factors should be considered:

  • Purity and Quality Control: Ensure the supplier provides detailed Certificates of Analysis (CoA) confirming high purity (≥99.0%) and adherence to strict quality control measures.
  • Production Capacity and Scalability: For large-scale production, the supplier must demonstrate the capacity to meet demand and support future growth.
  • Regulatory Compliance: Suppliers should be aware of and adhere to relevant pharmaceutical industry regulations and standards.
  • Pricing and Cost-Effectiveness: While quality is paramount, competitive pricing is essential for overall project viability. Sourcing from China can often offer cost advantages.
  • Supply Chain Reliability: A stable and transparent supply chain minimizes risks of production delays.

Companies like NINGBO INNO PHARMCHEM CO.,LTD. understand these demands and strive to be a trusted partner, offering high-quality 2,6-Dichloropurine backed by robust manufacturing processes and dedicated customer service. When you buy 2,6-Dichloropurine, you are investing in the foundation of critical pharmaceutical products.

In conclusion, for pharmaceutical companies and researchers, securing a dependable supply of 2,6-Dichloropurine is a strategic imperative. By partnering with reputable manufacturers and suppliers, you can ensure the quality, consistency, and timely availability needed to bring vital medications to market.