For procurement managers in the pharmaceutical sector, securing a reliable supply of critical intermediates is paramount. 2-Bromo-5-fluoro-3-nitropyridine stands out as a key building block, essential for the synthesis of a diverse range of active pharmaceutical ingredients (APIs). Understanding its properties and the best avenues for procurement can significantly streamline research and development processes.

Understanding 2-Bromo-5-fluoro-3-nitropyridine

This compound, identified by CAS number 652160-72-0, is a fluorinated nitropyridine derivative. Its molecular structure, featuring bromine, fluorine, and a nitro group on a pyridine ring, endows it with specific reactivity crucial for various organic transformations. Typically appearing as a light yellow powder with a purity often exceeding 98.0%, it serves as a versatile intermediate. Its electron-deficient aromatic system makes it particularly useful in reactions like nucleophilic aromatic substitution (SNAr) and palladium-catalyzed cross-couplings, which are cornerstones of modern medicinal chemistry.

Key Considerations for Procurement Managers

When seeking to buy 2-Bromo-5-fluoro-3-nitropyridine, several factors should guide your selection:

  1. Purity and Quality: The success of complex syntheses often hinges on the purity of starting materials. Opt for suppliers that provide detailed Certificates of Analysis (CoA) confirming high purity (≥98.0%) and low impurity profiles.
  2. Supplier Reliability: Establish relationships with reputable manufacturers and suppliers, preferably those with a strong track record in China's chemical industry. This ensures consistent quality and timely delivery, vital for project timelines.
  3. Pricing and Bulk Options: For large-scale R&D projects or commercial production, competitive pricing and the availability of bulk quantities are essential. Inquire about volume discounts and long-term supply agreements.
  4. Technical Support: A knowledgeable supplier can offer valuable technical insights into the compound's handling, storage, and reactivity, aiding your research team.

The Role of 2-Bromo-5-fluoro-3-nitropyridine in Drug Discovery

This intermediate is instrumental in constructing novel molecular scaffolds that exhibit promising biological activities. Researchers are actively investigating its derivatives for their potential as antimicrobial agents, anticancer compounds, and other therapeutic applications. Its incorporation into synthetic routes allows for the precise introduction of fluorine and nitro functionalities, which can modulate a drug candidate's pharmacokinetic and pharmacodynamic properties. For example, fluorination can enhance metabolic stability and lipophilicity, while the nitro group can be further modified to introduce amine functionalities, opening pathways to a vast array of derivative structures.

Where to Buy in China

When looking to purchase 2-Bromo-5-fluoro-3-nitropyridine, it is advisable to engage with established chemical manufacturers and distributors in China. Companies that specialize in fine chemical intermediates and pharmaceutical building blocks are likely to offer the highest quality products and competitive prices. Exploring online chemical marketplaces and directly contacting suppliers known for their specialization in pyridine derivatives can lead to excellent procurement opportunities. Always prioritize suppliers who can provide comprehensive technical documentation and support.

In conclusion, for pharmaceutical procurement managers, understanding the value and sourcing strategies for intermediates like 2-Bromo-5-fluoro-3-nitropyridine is crucial. By focusing on quality, reliability, and expert support, you can secure the essential materials needed to drive your drug discovery efforts forward. We are a leading manufacturer and supplier dedicated to providing the high-purity compounds your research demands.