For research scientists, product formulators, and procurement specialists in the pharmaceutical and fine chemical industries, identifying reliable sources for key intermediates is crucial. 2-Fluoro-5-hydroxypyridine (CAS 55758-32-2) is one such compound, widely recognized for its utility as a pharmaceutical intermediate. This guide aims to assist buyers in navigating the process of sourcing this essential chemical, focusing on quality, availability, and the advantages of working with Chinese manufacturers.

Understanding 2-Fluoro-5-hydroxypyridine

2-Fluoro-5-hydroxypyridine, also known by its synonym 6-fluoropyridin-3-ol, is a fluorinated pyridine derivative. Its molecular formula is C5H4FNO, and it typically appears as a white to off-white powder. The key characteristic driving its demand is its role as a versatile building block in organic synthesis, particularly for the development of pharmaceutical compounds. Its purity, often specified as ≥98% by GC or HPLC, is critical for ensuring the success of downstream synthetic steps and the quality of the final active pharmaceutical ingredient (API).

Key Applications and Why Purity Matters

The primary application for 2-Fluoro-5-hydroxypyridine lies in its use as a pharmaceutical intermediate. It is instrumental in the synthesis of various drug candidates, contributing unique structural and electronic properties that can enhance therapeutic efficacy. For instance, its fluorinated structure can improve pharmacokinetic profiles, such as increased metabolic stability and better cell permeability. The hydroxyl group also offers a convenient handle for further functionalization.

When you buy 2-Fluoro-5-hydroxypyridine, especially for pharmaceutical applications, ensuring high purity is non-negotiable. Impurities can lead to side reactions, reduced yields, and potentially contaminate the final API, posing significant regulatory and safety challenges. Therefore, sourcing from a reputable manufacturer in China that provides detailed Certificates of Analysis (CoA) is essential.

Navigating the Market: Price and Suppliers

The CAS 55758-32-2 price can vary based on purity, quantity, and supplier. As a buyer, it is advisable to compare quotes from multiple sources. When searching for high purity 6-fluoropyridin-3-ol for sale, look for suppliers that offer:

  • Clear specifications and guaranteed purity levels.
  • Reliable supply chain and consistent availability.
  • Responsive customer service and technical support.
  • Competitive pricing, especially for bulk orders.
  • Proper packaging and storage recommendations.

Several Chinese chemical companies specialize in producing and exporting pharmaceutical intermediates like 2-Fluoro-5-hydroxypyridine. By leveraging the strengths of the Chinese chemical manufacturing sector, you can often secure high-quality materials at competitive prices. It is always recommended to perform due diligence on potential suppliers, checking for certifications, customer reviews, and their track record in international trade.

In conclusion, securing a consistent and high-quality supply of 2-Fluoro-5-hydroxypyridine is vital for advancing pharmaceutical research. By understanding its properties and the market dynamics, buyers can effectively purchase this critical intermediate, ensuring the success of their drug development projects.