For procurement managers and R&D scientists in the pharmaceutical sector, sourcing high-quality raw materials is paramount. 2-Phenylisobutyric Acid (CAS 826-55-1) stands out as a critical intermediate, particularly for the synthesis of Fexofenadine hydrochloride. This article aims to guide you through understanding its specifications, applications, and how to effectively buy it from reliable suppliers.

Understanding 2-Phenylisobutyric Acid

Also known by synonyms such as 2-Methyl-2-phenylpropanoic Acid or alpha,alpha-Dimethyl phenyl Acetic Acid, this compound is typically supplied as a white crystalline powder. Its physicochemical properties, such as a melting point of 80-82°C and a boiling point of 270.5°C, are crucial for formulators to consider during process development. The high purity, often exceeding 97% or even 99.5% as specified by manufacturers, is non-negotiable for pharmaceutical applications to ensure the efficacy and safety of the final drug product.

Key Applications in Pharmaceutical Synthesis

The primary driver for demand for 2-Phenylisobutyric Acid is its role as a pivotal intermediate in the synthesis of Fexofenadine hydrochloride. Fexofenadine is a widely prescribed non-sedating antihistamine, making the consistent supply of its precursors vital. Beyond this, its utility as a versatile building block in various organic synthesis pathways makes it valuable for custom synthesis projects and the development of novel compounds. Researchers looking to expand their repertoire of synthesis materials should consider adding this to their procurement list.

Sourcing Strategies: Manufacturer vs. Distributor

When you are ready to purchase 2-Phenylisobutyric Acid, understanding where to source it from is key. For optimal pricing and guaranteed quality, procuring directly from a manufacturer in China is often the most advantageous approach. Manufacturers can provide detailed Certificates of Analysis (CoA), lot traceability, and can often accommodate larger bulk orders more efficiently. Distributors may offer convenience for smaller quantities, but direct sourcing typically yields better cost-effectiveness and direct access to technical support regarding product specifications and usage.

What to Look for in a Supplier

A reputable supplier of 2-Phenylisobutyric Acid should offer:

  • High Purity Standards: Look for products with purity levels of 97% minimum, with options for higher grades if required.
  • Comprehensive Documentation: Ensure the availability of CoA, MSDS, and other relevant technical data.
  • Stable Supply Chain: A manufacturer with robust production capabilities can guarantee consistent availability for your ongoing projects.
  • Competitive Pricing: Direct sourcing from a China manufacturer often leads to the best market price.
  • Responsive Customer Service: Clear communication and prompt responses to inquiries are essential, especially when dealing with international sourcing.

By focusing on these aspects, procurement professionals can secure a reliable supply of 2-Phenylisobutyric Acid, paving the way for successful pharmaceutical development and manufacturing. If you are seeking to buy this essential intermediate, consider reaching out to established chemical manufacturers for a comprehensive quote and sample.