For professionals in pharmaceutical research and development, securing high-quality chemical intermediates is paramount. 3-Fluoro-4-methoxyacetophenone (CAS 455-91-4) stands out as a critical building block, particularly in the synthesis of Active Pharmaceutical Ingredients (APIs) and various organic compounds. This article aims to guide potential buyers on sourcing this essential material, focusing on quality, competitive pricing, and reliable supply chains, especially from manufacturers in China.

Understanding 3-Fluoro-4-methoxyacetophenone

3-Fluoro-4-methoxyacetophenone, identified by its CAS number 455-91-4, is a fluorinated aromatic ketone. Its chemical structure makes it an invaluable precursor for a range of synthetic pathways. Typically appearing as a white powder, it possesses a melting point of 92-94°C, indicating its solid state at room temperature. Its chemical formula is C9H9FO2, with a molecular weight of 168.16. The compound's utility lies in its ability to participate in various organic reactions, enabling the creation of complex molecules vital for drug development.

Key Applications in Pharmaceutical Synthesis

The primary application of 3-Fluoro-4-methoxyacetophenone is as a pharmaceutical intermediate. It is frequently used in the synthesis of chalcone derivatives. Chalcones are known for their diverse biological activities and serve as precursors for other important compounds, including pyrazoles used in anti-inflammatory drugs. Furthermore, its structure lends itself to Mannich reactions, producing beta-amino-carbonyl compounds, which are also significant in medicinal chemistry. Researchers and product formulators actively seek this compound to advance their drug discovery pipelines.

Sourcing Strategies: Quality and Price Considerations

When looking to buy 3-Fluoro-4-methoxyacetophenone, it is crucial to partner with reputable manufacturers and suppliers. China has emerged as a significant hub for fine chemical production, offering a balance of quality and competitive pricing. For procurement managers and R&D scientists, identifying suppliers who can guarantee high purity (often exceeding 98%) is key to ensuring the success of downstream synthesis processes. Price is, of course, a major consideration, and direct sourcing from Chinese manufacturers can often yield significant cost savings without compromising on quality.

What to Look For in a Supplier

A reliable supplier of 3-Fluoro-4-methoxyacetophenone should offer:

  • High Purity Levels: Ensure the product meets or exceeds the required purity specifications for your application.
  • Certifications and Quality Control: Look for ISO certifications and robust quality control measures.
  • Consistent Supply and Lead Times: Reliability in delivery is critical for project timelines.
  • Competitive Pricing and Bulk Discounts: Negotiate for favorable terms, especially for larger orders.
  • Technical Support: Access to technical data and support can be invaluable.

As NINGBO INNO PHARMCHEM CO.,LTD., we are committed to being your preferred supplier for high-quality pharmaceutical intermediates. We understand the stringent requirements of the pharmaceutical industry and strive to provide exceptional products and services. If you are seeking to purchase 3-Fluoro-4-methoxyacetophenone, reach out to us for a competitive quote and to discuss your specific needs. We are dedicated to supporting your innovation and ensuring a seamless procurement experience.