For professionals in the chemical, pharmaceutical, and agrochemical sectors, sourcing high-quality intermediates is paramount to project success. 3-Fluorobenzyl Chloride (CAS 456-42-8) stands out as a versatile and critical building block for a wide array of synthetic applications. Understanding where and how to procure this compound can significantly impact your research and manufacturing timelines and outcomes.

What is 3-Fluorobenzyl Chloride?

3-Fluorobenzyl Chloride, also known by its IUPAC name 1-(chloromethyl)-3-fluorobenzene, is an organic compound characterized by a benzene ring substituted with a fluorine atom at the meta position and a chloromethyl group. Its molecular formula is C7H6ClF, and its CAS number is 456-42-8. This compound is a valuable intermediate due to the reactivity of its chloromethyl group, making it an excellent electrophile for nucleophilic substitution reactions.

Key Applications in Industry

The primary utility of 3-Fluorobenzyl Chloride lies in its role as a synthetic intermediate. Its structure allows for its incorporation into larger molecules, making it indispensable in several key industries:

  • Pharmaceutical Synthesis: It is frequently employed in the synthesis of Active Pharmaceutical Ingredients (APIs) and novel drug candidates. The fluorine atom can influence a drug's metabolic stability, lipophilicity, and binding affinity. Researchers actively seek reliable suppliers of this chemical to advance their drug discovery programs.
  • Agrochemical Development: In the agrochemical sector, 3-Fluorobenzyl Chloride serves as a precursor for various pesticides, herbicides, and fungicides. The introduction of fluorine can enhance the efficacy and environmental profile of these agricultural chemicals.
  • Fine Chemical Manufacturing: Beyond pharmaceuticals and agrochemicals, it is used in the synthesis of other specialty chemicals and advanced materials where specific fluorinated functionalities are required.

Sourcing and Quality Considerations

When looking to buy 3-Fluorobenzyl Chloride, quality and reliability are non-negotiable. For B2B procurement, identifying a reputable manufacturer and supplier, particularly one based in China known for its chemical manufacturing capabilities, is crucial. Key factors to consider include:

  • Purity: Typically, a purity of 95% or higher is desirable for most synthetic applications. Always check the Certificate of Analysis (COA) provided by the supplier.
  • Supplier Reputation: Look for established chemical suppliers with a history of consistent quality and customer service. Online platforms and industry directories can help identify potential partners.
  • Pricing and Availability: While price is a factor, it should be balanced with quality and supply stability. Contacting a manufacturer directly for a quote can provide the best insights into current market rates and bulk purchase options.
  • Logistics and Packaging: Ensure the supplier can handle appropriate packaging and shipping for chemical intermediates, adhering to safety regulations.

Finding a Reliable Manufacturer in China

China has emerged as a global hub for chemical manufacturing, offering competitive pricing and a vast production capacity. When sourcing 3-Fluorobenzyl Chloride from China, it is beneficial to work with companies that:

  • Have robust quality control systems (e.g., ISO certification).
  • Provide detailed technical data sheets and safety data sheets (SDS).
  • Offer responsive customer support for inquiries and orders.
  • Have experience in international shipping and export procedures.

By focusing on these aspects, procurement managers and R&D scientists can confidently source the 3-Fluorobenzyl Chloride (CAS 456-42-8) needed to drive their projects forward. Engaging with trusted manufacturers ensures not only the quality of the material but also the stability of your supply chain.