For businesses operating in the pharmaceutical and fine chemical sectors, the reliable sourcing of high-quality intermediates is fundamental to operational success. Among these vital compounds is 4-Chloro-2,3-Dimethylpyridine 1-Oxide, identified by its CAS number 59886-90-7. This chemical is particularly critical for its role in the synthesis of Rabeprazole, a widely used medication for gastrointestinal issues. Understanding how to source this intermediate effectively, including its key properties and the advantages of working with reputable suppliers, is essential.

4-Chloro-2,3-Dimethylpyridine 1-Oxide, also known as 4-Chloro-2,3-dimethylpyridine N-oxide, possesses specific characteristics that make it suitable for its intended applications. Its molecular formula is C7H8ClNO, with a molecular weight of 157.598 g/mol. Physically, it appears as an off-white to light yellow crystalline powder. Key technical specifications that buyers should look for include a high assay, typically ≥98.0% by HPLC, and a low moisture content, usually ≤0.5%. These parameters ensure the compound's purity and stability, which are non-negotiable in pharmaceutical manufacturing. The melting point ranges from 103-105°C, and its boiling point is approximately 338.5±37.0 °C.

The primary industrial application for 4-Chloro-2,3-Dimethylpyridine 1-Oxide is its use as a crucial intermediate in the multi-step synthesis of Rabeprazole. Rabeprazole is a proton pump inhibitor that effectively treats conditions such as heartburn, GERD, and peptic ulcers by reducing stomach acid production. The quality of this pyridine derivative directly influences the yield and purity of the final Rabeprazole API. Consequently, pharmaceutical companies and contract manufacturers place a high premium on sourcing this intermediate from reliable manufacturers who adhere to stringent quality control protocols.

China has become a global leader in the production and supply of fine chemicals and pharmaceutical intermediates, and 4-Chloro-2,3-Dimethylpyridine 1-Oxide is no exception. The country offers a vast network of manufacturers and suppliers, providing competitive pricing and significant production capacities. When sourcing from China, it is advisable to partner with established companies that can provide comprehensive product documentation, including Certificates of Analysis (CoA), and demonstrate compliance with international quality standards like ISO. NINGBO INNO PHARMCHEM CO.,LTD. is an example of a Chinese chemical company focused on delivering high-quality intermediates for the global market, including this critical pyridine derivative.

Beyond its pharmaceutical role, the compound is also utilized in academic and industrial research settings for its properties in heterocyclic chemistry. Its structure can be modified or incorporated into larger molecules, opening avenues for the discovery of new chemical entities with potential therapeutic or material science applications. For companies looking to buy 4-Chloro-2,3-Dimethylpyridine 1-Oxide, engaging with suppliers who understand the specific requirements of the chemical industry is paramount.

In summary, effective sourcing of 4-Chloro-2,3-Dimethylpyridine 1-Oxide requires a clear understanding of its specifications and its critical role as a Rabeprazole intermediate. By prioritizing quality, reliability, and partnering with experienced suppliers, businesses can ensure a stable supply chain for this essential chemical building block.