For procurement managers operating within the chemical and pharmaceutical industries, sourcing critical intermediates like 4-Fluorophenylacetic acid (CAS 405-50-5) efficiently and reliably is a key operational challenge. This compound serves as a vital link in many complex synthesis chains, particularly in the development of pharmaceuticals. Understanding its properties, applications, and the best practices for sourcing is essential for ensuring supply chain stability and product quality.

What is 4-Fluorophenylacetic Acid and Why is it Important?

4-Fluorophenylacetic acid, also known by its chemical name 2-(4-fluorophenyl)acetic acid, is an organic compound with the CAS number 405-50-5. It is typically a white crystalline powder. Its significance stems from its role as a versatile intermediate in organic synthesis. The presence of a fluorine atom on the phenyl ring modifies the electronic and physical properties of the molecule, making it particularly valuable in applications where enhanced stability, lipophilicity, or specific binding characteristics are required. This is especially true in the pharmaceutical sector, where fluorine incorporation is a common strategy to improve drug efficacy and pharmacokinetic profiles.

Primary Applications for Procurement

Procurement managers will primarily source 4-Fluorophenylacetic acid for its use as an intermediate in:

  • Pharmaceutical Manufacturing: It is a key precursor for synthesizing various APIs, including fluorinated anesthetics and compounds that act as receptor antagonists, crucial for developing new medications.
  • Agrochemical Synthesis: The compound can also be used in the development of specialized agrochemicals.
  • Fine Chemical Production: Its reactive nature makes it suitable for creating a range of other fine chemicals and research compounds.

The demand for this intermediate is driven by the continuous research and development efforts in these sectors. Therefore, securing a stable supply is a strategic priority.

Key Factors for Sourcing 4-Fluorophenylacetic Acid from China

When looking to buy 4-Fluorophenylacetic acid, particularly from China, procurement professionals should evaluate suppliers based on several critical criteria:

  • Quality and Purity: Verify that the supplier can consistently provide material meeting your required specifications. Request Certificates of Analysis (CoA) and consider third-party verification if necessary. The typical assay is around 98% or higher.
  • Production Capacity: Ensure the manufacturer has sufficient capacity to meet your ongoing demand, whether for pilot-scale batches or large commercial volumes.
  • Regulatory Compliance: Confirm that the supplier adheres to relevant industry standards and can provide necessary documentation for your region.
  • Pricing and Payment Terms: Obtain quotes and negotiate favorable pricing and payment terms, considering whether prices are EXW, FOB, or CIF.
  • Logistics and Lead Times: Understand shipping options, delivery times, and the reliability of the supplier's logistics partners.
  • Technical Support: A supplier that offers technical support can be invaluable for troubleshooting or optimizing synthesis processes.

Working with a reputable 4-Fluorophenylacetic acid supplier in China can offer significant cost advantages and access to advanced manufacturing capabilities.

Initiating a Quote and Ensuring Supply Continuity

To procure 4-Fluorophenylacetic acid, the first step is typically to submit an inquiry with your specific requirements, including quantity, desired purity, and delivery location. A prompt and detailed response from the supplier, including a quote and lead time, is a good indicator of their responsiveness. Building a strong relationship with a trusted manufacturer is key to ensuring long-term supply continuity for this essential intermediate.

Conclusion

4-Fluorophenylacetic acid (CAS 405-50-5) is a foundational intermediate with broad applications, particularly in the pharmaceutical sector. For procurement managers, understanding the sourcing landscape, focusing on quality, and partnering with reliable China-based manufacturers are critical steps to securing a stable supply and supporting the critical synthesis needs of their organizations.