For pharmaceutical formulators and chemists engaged in drug development, the consistent availability of high-quality raw materials is non-negotiable. 6-Bromopurine (CAS 767-69-1) is a prime example of such a critical intermediate. This article aims to guide formulators on understanding and sourcing this essential compound, highlighting its importance and the benefits of working with experienced suppliers from China.

The Chemical Profile of 6-Bromopurine

6-Bromopurine, with the CAS number 767-69-1, is a white to pale yellow crystalline powder characterized by its odorless nature and specific solubility profiles. It is readily soluble in DMSO and DMF, sparingly soluble in water, making it amenable to various reaction conditions common in pharmaceutical synthesis. Its melting point, typically between 202-205°C with decomposition, indicates its stability under controlled storage conditions (2-8°C under inert atmosphere).

Applications in Pharmaceutical Formulation

Formulators leverage 6-Bromopurine for several key applications:

  • Synthesis of Nucleotide Analogs: It serves as a vital precursor in creating modified nucleotides, which are fundamental to developing targeted therapies for viral infections and cancers. The precise structure of 6-Bromopurine allows for controlled modifications to mimic or interfere with natural nucleic acids.
  • Intermediate for Novel APIs: Beyond nucleotide analogs, 6-Bromopurine is extensively used as a versatile intermediate in the synthesis of a broad spectrum of APIs. Its purine core makes it particularly useful in developing compounds that interact with biological pathways involving purine metabolism.
  • Research and Development: In R&D settings, the compound is valued for its utility in cross-coupling reactions and as a building block for exploring new chemical entities with potential therapeutic benefits.

Navigating the Supply Chain: Key Considerations for Buyers

When you decide to purchase 6-Bromopurine, it is essential to partner with suppliers who can guarantee quality and reliability. Key factors to consider include:

  • Purity and Specifications: Ensure the supplier provides detailed Certificates of Analysis (CoA) confirming purity levels (e.g., ≥98.5% HPLC) and adherence to standards like residual solvents (ICH Q3C).
  • Manufacturing Capabilities: Look for manufacturers with robust quality management systems and experience in handling heterocyclic compounds and brominated intermediates.
  • Supply Stability and Pricing: Establishing a relationship with a supplier that offers consistent availability and competitive pricing is critical for long-term projects. Manufacturers in China are often well-positioned to meet these demands.
  • Regulatory Compliance: Verify that the supplier can provide necessary documentation and comply with international regulations relevant to pharmaceutical intermediates.

By carefully selecting your supplier, pharmaceutical formulators can secure a dependable source of 6-Bromopurine, thereby streamlining their development processes and ensuring the production of safe and effective medicines. We are committed to being that reliable partner for your chemical needs.