For pharmaceutical companies engaged in the development and manufacturing of targeted cancer therapies like Afatinib, the reliable sourcing of high-quality intermediates is paramount. One such crucial component is Trans-4-Dimethylaminocrotonic Acid Hydrochloride (CAS 848133-35-7). This article aims to guide procurement managers and R&D scientists in effectively sourcing this vital compound, emphasizing key considerations to ensure optimal results and a seamless supply chain.

Understanding the Importance of Trans-4-Dimethylaminocrotonic Acid Hydrochloride

Trans-4-Dimethylaminocrotonic Acid Hydrochloride is a specialized organic compound that serves as a critical building block in the multi-step synthesis of Afatinib, a potent tyrosine kinase inhibitor used in the treatment of certain types of lung cancer. Its specific chemical structure and purity directly impact the efficacy and safety of the final Active Pharmaceutical Ingredient (API). Therefore, selecting the right trans-4-dimethylaminocrotonic acid hydrochloride manufacturer is a strategic decision for any pharmaceutical firm.

Key Factors When Sourcing: Quality, Purity, and Specifications

When looking to buy trans-4-dimethylaminocrotonic acid hydrochloride, the primary focus should be on product quality and purity. Reputable suppliers will provide detailed Certificates of Analysis (CoA) confirming parameters such as appearance (typically a white powder), assay (commonly ≥98.0%), and molecular weight (165.62 g/mol). Understanding the CAS number, 848133-35-7, is also essential for accurate identification and sourcing. Engaging with a high purity trans-4-dimethylaminocrotonic acid hydrochloride supplier ensures that the intermediate meets the stringent requirements of pharmaceutical synthesis, minimizing the risk of impurities that could affect downstream processes or the final drug product.

Navigating the Supply Chain: Manufacturers and Pricing

Identifying reliable trans-4-dimethylaminocrotonic acid hydrochloride manufacturers in China and other key regions is crucial for securing a stable supply. Working directly with manufacturers can often lead to more competitive pricing. When requesting a trans-4-dimethylaminocrotonic acid hydrochloride price quote, it's advisable to inquire about bulk discounts, lead times, and minimum order quantities. A transparent pricing structure and clear communication regarding delivery schedules are hallmarks of a dependable supplier.

Beyond Quality: Reliability and Partnership

Choosing a supplier for a critical intermediate like Trans-4-Dimethylaminocrotonic Acid Hydrochloride is more than just a transaction; it’s about building a partnership. A good supplier will offer consistent product quality, reliable delivery, and responsive customer support. They should be able to provide technical data, safety information (MSDS), and be transparent about their manufacturing processes and quality assurance systems. As a leading provider, we are committed to supporting your pharmaceutical development with unparalleled quality and service.

For those seeking a dependable source for this vital intermediate, exploring options from established pharmaceutical chemical suppliers is recommended. Securing a consistent supply of high-quality Trans-4-Dimethylaminocrotonic Acid Hydrochloride is a foundational step towards successful Afatinib production.