For pharmaceutical manufacturers, the reliable sourcing of high-quality intermediates is paramount to the success of drug production. Apixaban, a widely prescribed anticoagulant, requires specific, high-purity intermediates for its synthesis. This article aims to guide purchasing managers and R&D scientists in identifying and securing these critical raw materials from reputable suppliers.

The primary intermediate in question is Ethyl 6-(4-aminophenyl)-1-(4-methoxyphenyl)-7-oxo-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridine-3-carboxylate, commonly known by its CAS number 503615-07-4. Ensuring the purity of this compound, typically specified at ≥98.0%, is crucial. Impurities in intermediates can lead to reduced yields, complex purification steps, and potential quality issues in the final Active Pharmaceutical Ingredient (API). Therefore, when looking to buy this intermediate, prioritizing suppliers who provide detailed Certificates of Analysis (CoA) with comprehensive analytical data, such as HPLC purity, is essential.

When evaluating potential manufacturers and suppliers, several factors come into play. Geographical location, for instance, can influence logistics and lead times. Suppliers based in China often offer competitive pricing due to established manufacturing infrastructure. However, proximity alone is not sufficient; a supplier's track record, adherence to quality standards (like GMP where applicable for intermediates), and communication responsiveness are key indicators of reliability. Companies looking for a stable supply chain should inquire about production capacity and their ability to handle large-scale orders, ensuring they can meet ongoing manufacturing demands.

The price of Ethyl 6-(4-aminophenyl)-1-(4-methoxyphenyl)-7-oxo-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridine-3-carboxylate can vary based on purity, quantity, and the supplier. Requesting multiple quotes from different manufacturers is a standard practice to secure the best possible terms. For significant quantities, negotiating bulk purchase agreements can lead to substantial cost savings. Remember to factor in shipping costs, import duties, and potential lead times when comparing offers.

For those involved in the synthesis of Apixaban or related compounds, understanding the role of specific intermediates is vital. This particular compound serves as a key building block, enabling the precise construction of the Apixaban molecule. Engaging with a dedicated pharmaceutical intermediate supplier that understands these nuances can streamline the procurement process and mitigate risks associated with complex chemical synthesis projects. We, as a leading manufacturer in China, are committed to providing high-purity intermediates and excellent customer service. We encourage you to contact us for a competitive quote and to discuss your specific needs for Apixaban intermediates.