For pharmaceutical manufacturers focused on producing Atorvastatin Calcium, securing a consistent and high-quality supply of key intermediates is paramount. Among these, (4R,6R)-tert-Butyl-6-cyanomethyl-2,2-dimethyl-1,3-dioxane-4-acetate, identified by CAS number 125971-94-0, stands out as a crucial building block. This article offers guidance for procurement managers and R&D scientists on how to effectively source this vital compound.

Understanding the Intermediate's Significance

(4R,6R)-tert-Butyl-6-cyanomethyl-2,2-dimethyl-1,3-dioxane-4-acetate is essential for constructing the specific molecular structure required for Atorvastatin's efficacy as a cholesterol-lowering drug. Its high purity and correct stereochemistry are non-negotiable for ensuring the quality and pharmacological activity of the final Active Pharmaceutical Ingredient (API). When looking to buy this intermediate, prioritize suppliers who can provide detailed Certificates of Analysis (CoA) confirming purity levels, typically above 99.5%, and adherence to international pharmacopoeial standards such as USP, BP, and EP.

Key Considerations for Procurement

As a procurement manager, several factors should guide your purchasing decisions. Firstly, supplier reliability is critical. Investigate potential manufacturers or suppliers for their production capacity, quality control systems (e.g., GMP certification), and track record in the pharmaceutical supply chain. A supplier based in China, for instance, can often offer competitive pricing for chemicals like CAS 125971-94-0, but due diligence is essential.

Secondly, price and commercial terms are important. While cost-effectiveness is a goal, it should not come at the expense of quality. Requesting quotes from multiple manufacturers allows for comparison. Look for suppliers who offer transparent pricing and flexible order quantities, catering to both pilot-scale R&D and large-scale commercial production. Understanding minimum order quantities (MOQ) and lead times is also vital for production planning.

Thirdly, regulatory compliance and documentation are key. Ensure that the supplier can provide necessary documentation, including Safety Data Sheets (SDS), Technical Data Sheets (TDS), and any relevant manufacturing certifications. This paperwork is essential for your company's internal quality assurance and regulatory submissions.

R&D Scientist's Perspective on Sourcing

For research and development scientists, the focus often leans towards product consistency and availability for experimental batches. When you need to purchase (4R,6R)-tert-Butyl-6-cyanomethyl-2,2-dimethyl-1,3-dioxane-4-acetate for initial studies or process optimization, ensure the supplier can provide smaller, research-grade quantities. The optical activity, typically around [α]20/D 1.0°, c = 1 in chloroform, is another critical parameter to verify for stereochemical integrity.

Engaging with a supplier's technical team can provide valuable insights into the intermediate's handling, storage requirements (e.g., storage at 2-8°C), and potential reactivity in your specific synthetic pathways. Early collaboration with a chemical manufacturer can prevent downstream issues and accelerate your development timeline.

Navigating the Market for CAS 125971-94-0

The global market offers numerous suppliers for pharmaceutical intermediates. When searching for manufacturers of (4R,6R)-tert-Butyl-6-cyanomethyl-2,2-dimethyl-1,3-dioxane-4-acetate, look for those specializing in API synthesis or fine chemicals. Many reputable Chinese chemical suppliers are well-equipped to meet the demanding specifications of the pharmaceutical industry. Proactive communication and clear specification requirements are key to establishing a successful supplier relationship. By understanding these critical aspects, pharmaceutical companies can confidently buy the necessary intermediates, ensuring the efficient and high-quality production of Atorvastatin Calcium.