In the intricate world of chemical synthesis, sourcing high-quality intermediates is paramount for successful research and product development. Among these essential compounds is Boc-D-Proline, also known as N-Boc-D-proline or by its CAS number 37784-17-1. This protected amino acid derivative serves as a critical building block, particularly in the pharmaceutical industry and advanced peptide synthesis. For procurement managers and research scientists, understanding where to buy Boc-D-Proline and what to look for in a supplier is key to ensuring project success.

Why Boc-D-Proline is Indispensable

Boc-D-Proline is valued for its protected nature, with the tert-butoxycarbonyl (Boc) group safeguarding the amine functionality of D-proline. This protection is vital during multi-step synthesis, preventing unwanted reactions and allowing for precise control over chemical transformations. Its applications are diverse and impactful:

  • Pharmaceutical Intermediate: It is a crucial intermediate in the synthesis of various active pharmaceutical ingredients (APIs). Notably, it plays a role in the creation of histone deacetylase (HDAC) inhibitors, a class of drugs investigated for their potential in treating cancers and other diseases. It's also used in the development of potent and selective nonpeptide inhibitors of caspases 3 and 7.
  • Peptide Synthesis: In solid-phase peptide synthesis, Boc-D-Proline is frequently employed to introduce D-proline residues into peptide sequences. D-amino acids can confer unique structural and functional properties to peptides, enhancing their stability and bioactivity.
  • Research and Development: Its role as a versatile chemical reagent makes it indispensable for academic and industrial research laboratories exploring new molecular entities and therapeutic targets.

Key Considerations When Purchasing Boc-D-Proline

When looking to buy Boc-D-Proline, several factors should guide your selection process to ensure you receive a product that meets your stringent requirements. These include:

  • Purity: High purity is essential for consistent and reproducible results. Look for suppliers that specify a purity level of u226598% (HPLC).
  • CAS Number: Confirming the CAS number 37784-17-1 is crucial to ensure you are sourcing the correct isomer and compound.
  • Physical Properties: Boc-D-Proline typically appears as a white powder, with specifications like low loss on drying (u22640.5%) indicating high quality.
  • Manufacturer Reputation: Partnering with a reputable manufacturer or supplier, particularly one based in China with a strong track record, can guarantee product quality and reliability.
  • Price and Availability: For both R&D and commercial-scale production, competitive pricing and consistent availability are critical. Inquire about bulk discounts from your chosen manufacturer.

Finding a Reliable Supplier

For many industries, securing a dependable source for chemical intermediates like Boc-D-Proline is a strategic advantage. Manufacturers specializing in fine chemicals and pharmaceutical intermediates often provide comprehensive documentation, including Certificates of Analysis (CoA), and can cater to various packaging requirements, from grams for research to kilograms for production. When you need to purchase Boc-D-Proline, investigating Chinese chemical suppliers can yield cost-effective solutions without compromising on quality. Many offer efficient logistics and dedicated customer support, making international procurement smoother.

By prioritizing purity, verifying specifications, and choosing a trustworthy manufacturer, you can ensure that your procurement of Boc-D-Proline effectively supports your critical research and manufacturing endeavors.