For pharmaceutical companies and chemical researchers, sourcing reliable and high-quality chiral intermediates is paramount. Among these essential building blocks, (R)-2-(1-Hydroxyethyl)pyridine, identified by CAS number 27911-63-3, stands out for its utility in complex organic synthesis, particularly within the pharmaceutical industry. This article aims to guide procurement managers and R&D scientists in understanding and acquiring this critical compound.

Understanding (R)-2-(1-Hydroxyethyl)pyridine

(R)-2-(1-Hydroxyethyl)pyridine is a chiral alcohol derivative of pyridine. Its chemical formula is C7H9NO, with a molecular weight of 123.15 g/mol. It is typically supplied as a white solid and possesses a boiling point of approximately 210.6 °C at 760 mmHg. The 'R' designation signifies its specific stereochemical configuration, which is often crucial for the biological activity of the final drug product.

As a pharmaceutical intermediate, its primary role is in the synthesis of Active Pharmaceutical Ingredients (APIs). The pyridine ring, coupled with the chiral hydroxyl-bearing ethyl side chain, offers versatile reaction sites for constructing more complex molecular architectures. This makes it an indispensable component in the development of new therapeutics.

Key Applications in Pharmaceutical Development

The demand for enantiopure compounds in drug discovery and development continues to grow. (R)-2-(1-Hydroxyethyl)pyridine is valuable for:

  • Stereoselective Synthesis: Its defined chirality allows for the precise construction of chiral drug molecules, minimizing the presence of less active or potentially harmful enantiomers.
  • Building Blocks for APIs: It serves as a key starting material or intermediate in multi-step syntheses of various pharmaceuticals, contributing specific structural motifs and chiral centers.
  • Research & Development: Academic and industrial researchers frequently utilize this compound for exploring novel synthetic routes and discovering new chemical entities.

Sourcing Strategies for Procurement Managers

When looking to buy (R)-2-(1-Hydroxyethyl)pyridine, procurement managers should focus on several key aspects:

  • Supplier Reliability: Partnering with a reputable manufacturer and supplier is crucial. Look for suppliers with a proven track record, robust quality control systems, and a commitment to timely delivery. Many experienced manufacturers in China offer this compound.
  • Purity and Specifications: Ensure the supplier can provide certificates of analysis (CoA) that clearly state the purity (often aiming for 99% min) and chiral purity (typically ≥98.0%) to meet regulatory and R&D requirements.
  • Pricing and Quotation: Obtaining competitive prices from manufacturers is important for cost-effective production. Requesting detailed quotes that include delivery terms and payment options is a standard practice when sourcing this chemical.
  • Technical Support: A good supplier will offer technical support, including information on handling, storage, and potential applications.

Choosing a Chinese Manufacturer

China has emerged as a global hub for chemical manufacturing, offering a wide range of pharmaceutical intermediates at competitive prices. When sourcing (R)-2-(1-Hydroxyethyl)pyridine from China, it is advisable to work with established companies that prioritize quality and have export experience. Companies specializing in fine chemicals and pharmaceutical intermediates are your best bet. They often provide comprehensive services, from initial inquiry to product delivery, ensuring a smooth procurement process.

In conclusion, (R)-2-(1-Hydroxyethyl)pyridine (CAS 27911-63-3) is a critical chiral intermediate for the pharmaceutical industry. By understanding its properties and employing smart sourcing strategies, procurement professionals can secure a high-quality and cost-effective supply from reliable manufacturers. When you need a trusted partner for this and other pharmaceutical intermediates, consider the specialized offerings from leading Chinese chemical suppliers.