For pharmaceutical companies engaged in the development and manufacturing of life-saving antibiotics, securing a consistent supply of high-quality intermediates is paramount. Among these critical components, compounds like 4-Acetoxy-3-(1-(tert-butyldimethylsilyloxy)ethyl)azetidin-2-one (CAS: 76855-69-1) play a pivotal role in the synthesis of potent drugs such as Doripenem. This article aims to guide procurement managers and R&D scientists in identifying reliable sources for these essential pharmaceutical building blocks, particularly focusing on identifying reputable manufacturers and suppliers in China.

Doripenem is a broad-spectrum carbapenem antibiotic known for its efficacy against a wide range of Gram-positive and Gram-negative bacteria, including those resistant to other antibiotics. Its complex molecular structure necessitates the use of specialized, high-purity intermediates during synthesis. The intermediate 4-Acetoxy-3-(1-(tert-butyldimethylsilyloxy)ethyl)azetidin-2-one is one such critical precursor. Its precise stereochemistry and purity are directly correlated with the efficacy and safety of the final Doripenem product.

When sourcing this intermediate, buyers often look for key specifications such as a high assay (typically ≥97.0% by HPLC), a defined melting point range (often 103-109°C), and a consistent appearance, usually a white crystalline powder. The CAS number 76855-69-1 is the universal identifier, ensuring you are procuring the correct chemical entity. Understanding these specifications is crucial for quality control and regulatory compliance.

For businesses looking to buy 4-Acetoxy-3-(1-(tert-butyldimethylsilyloxy)ethyl)azetidin-2-one, China has emerged as a significant global hub for pharmaceutical intermediate manufacturing. Numerous Chinese chemical manufacturers specialize in producing these complex molecules, often offering competitive pricing and robust production capabilities. However, selecting the right supplier requires diligent research. Key factors to consider include the manufacturer's adherence to quality management systems (like ISO certifications), their experience in handling chiral synthesis, their production capacity, and their ability to provide necessary documentation, such as Certificates of Analysis (CoA).

Procurement managers should also inquire about lead times, packaging options (commonly 25 kg drums), and storage recommendations (cool, ventilated places) to ensure product integrity from the point of manufacture to your facility. Building a relationship with a trusted supplier for critical intermediates like CAS 76855-69-1 can significantly streamline your R&D and production pipelines. Leveraging platforms that connect buyers with verified manufacturers can simplify the sourcing process and provide access to detailed product information and quotations.

Ultimately, the successful synthesis of advanced antibiotics like Doripenem hinges on the quality of the raw materials and intermediates used. By prioritizing high-purity pharmaceutical intermediates and partnering with reputable manufacturers in China, pharmaceutical companies can ensure the efficacy, safety, and cost-effectiveness of their products, contributing to better patient outcomes worldwide.