For procurement managers in the pharmaceutical and fine chemical industries, sourcing critical intermediates like Ethyl 4-amino-1H-imidazole-5-carboxylate (CAS 21190-16-9) is a strategic imperative. This compound, a vital building block, plays a significant role in the synthesis of Active Pharmaceutical Ingredients (APIs) and other complex organic molecules. Understanding the landscape of its manufacturing and supply is crucial for ensuring cost-effectiveness, consistent quality, and supply chain resilience.

When looking to purchase Ethyl 4-amino-1H-imidazole-5-carboxylate, procurement professionals often turn to manufacturers and suppliers in China, known for their robust chemical manufacturing capabilities and competitive pricing. Identifying reliable suppliers is paramount. Key considerations include the supplier's experience in producing pharmaceutical intermediates, their adherence to quality control standards (such as ISO certifications), and their ability to provide comprehensive documentation, including Certificates of Analysis (CoA) and Material Safety Data Sheets (MSDS).

The chemical itself, Ethyl 4-amino-1H-imidazole-5-carboxylate, is characterized by its imidazole ring, an amino group, and an ethyl ester moiety. This structure endows it with significant reactivity, making it a versatile intermediate. Its CAS number, 21190-16-9, is the universal identifier used in sourcing and regulatory contexts. When inquiring about its price, it's important to consider factors such as order volume, purity requirements, and current market conditions. Obtaining multiple quotes from different manufacturers is a standard procurement practice to ensure the best possible price.

For example, a procurement manager might search for 'Ethyl 4-amino-1H-imidazole-5-carboxylate manufacturer China' or 'CAS 21190-16-9 supplier price'. This type of targeted search helps identify potential vendors. Suppliers often showcase their product offerings, detailing specifications like purity (e.g., 98% or 99%), physical appearance (typically a white to gray solid), and packaging options. Some suppliers may also offer custom synthesis services for related derivatives, further enhancing their value proposition.

The synthesis of Ethyl 4-amino-1H-imidazole-5-carboxylate itself involves multi-step processes. While detailed synthetic routes are beyond the scope of a procurement-focused article, understanding that it's a product of sophisticated organic synthesis reinforces the importance of sourcing from experienced manufacturers. Advanced synthetic techniques, including microwave-assisted synthesis and green chemistry approaches, are continually being developed to improve efficiency and reduce environmental impact, which can also influence the cost and availability of the intermediate.

In conclusion, for procurement managers tasked with acquiring Ethyl 4-amino-1H-imidazole-5-carboxylate, a strategic approach involving thorough supplier vetting, competitive price negotiation, and a clear understanding of quality requirements is essential. Partnering with a reputable manufacturer in China can provide access to high-quality materials at favorable price points, thereby supporting efficient drug development and production workflows.