For researchers and chemists involved in peptide synthesis, acquiring high-quality Fmoc-Lys(Mtt)-OH (CAS: 167393-62-6) is a critical step. This lysine derivative, N-alpha-Fmoc-N-epsilon-(4-methyltrityl)-L-lysine, is indispensable for creating peptides with precisely controlled lysine modifications. This buyer's guide aims to assist you in sourcing this essential reagent effectively, focusing on quality, reliability, and cost-efficiency.

Understanding the Product: Fmoc-Lys(Mtt)-OH

Fmoc-Lys(Mtt)-OH is a building block for peptide synthesis where the epsilon-amino group of lysine is protected by the acid-labile 4-methyltrityl (Mtt) group. This protection strategy is valued for its orthogonality to other protecting groups commonly used in Solid Phase Peptide Synthesis (SPPS), allowing for selective deprotection and subsequent functionalization of the lysine side chain. This capability is crucial for synthesizing branched peptides, site-specifically labeled peptides, and cyclic peptides.

Key Considerations When Purchasing:

  • Purity: The most important factor is the purity of the Fmoc-Lys(Mtt)-OH. High purity, typically exceeding 99% as determined by HPLC, ensures that reactions proceed cleanly and efficiently, minimizing unwanted side products and ensuring the integrity of the final peptide. Always request a Certificate of Analysis (COA) to verify these specifications.
  • Manufacturer Reliability: When you buy Fmoc-Lys(Mtt)-OH, partnering with a reputable manufacturer is paramount. Look for suppliers with a proven track record in producing high-quality amino acid derivatives for the pharmaceutical and biotech industries. A good supplier will also offer technical support and responsive customer service.
  • Pricing and Bulk Orders: For larger research projects or commercial production, obtaining competitive pricing for bulk quantities is a significant consideration. Investigating pricing from various manufacturers, especially those based in China, can offer substantial cost savings without compromising on quality. Negotiating pricing for larger orders is a standard practice.
  • CAS Number Verification: Always confirm the CAS number (167393-62-6) to ensure you are receiving the correct chemical entity.
  • Storage and Handling: Understand the recommended storage conditions (often requiring refrigeration at -20°C) to maintain the product's stability and shelf life.

Finding the Right Supplier

When searching for a supplier of Fmoc-Lys(Mtt)-OH, consider manufacturers that specialize in peptide synthesis reagents. Online chemical marketplaces and directories can be valuable resources. Engaging directly with a manufacturer often provides the best insight into their production capabilities and quality control measures. If you are planning to purchase in significant quantities, reach out for a formal quote to discuss your specific needs and potential volume discounts.

By carefully considering these factors, you can confidently source high-quality Fmoc-Lys(Mtt)-OH, enabling successful and efficient peptide synthesis for your research and development endeavors. Remember, the right chemical supplier is an extension of your laboratory's capabilities.