For procurement managers and R&D scientists in the pharmaceutical and fine chemical industries, sourcing high-quality intermediates is paramount. Among these, 1-Boc-piperidine-4-carboxaldehyde (CAS: 137076-22-3) stands out as a critical building block. Understanding where to buy this compound and its key attributes can significantly impact project timelines and success rates. This guide focuses on providing actionable insights for B2B buyers looking to purchase 1-Boc-piperidine-4-carboxaldehyde from reputable manufacturers, particularly those based in China.

Understanding 1-Boc-piperidine-4-carboxaldehyde: Properties and Applications

1-Boc-piperidine-4-carboxaldehyde, also known by its IUPAC name tert-butyl 4-formylpiperidine-1-carboxylate, is a white crystal powder with a purity typically exceeding 97%. Its molecular formula is C11H19NO3, and its molecular weight is approximately 213.28 g/mol. This compound serves as a versatile intermediate in organic synthesis, primarily within the pharmaceutical sector. Its aldehyde functional group, coupled with the protected piperidine ring, makes it an ideal starting material for a wide array of complex molecule constructions.

Its applications are diverse, ranging from the synthesis of Pim-1 inhibitors and selective GPR119 agonists for type II diabetes to M-tropic (R5) HIV-1 replication inhibitors and HDAC inhibitors. Furthermore, it's employed in the development of selective 5-HT6 antagonists and in three-component vinylogous Mannich reactions. The consistent demand for this compound underscores its importance in cutting-edge drug discovery and development projects.

Key Considerations for B2B Buyers: Purity, Pricing, and Supplier Reliability

When purchasing 1-Boc-piperidine-4-carboxaldehyde, B2B buyers prioritize several factors:

  • Purity: A minimum purity of 97% is generally required to ensure the efficacy and reproducibility of downstream synthetic steps. Manufacturers in China are increasingly offering high-purity grades.
  • Pricing: Competitive pricing is crucial for cost-effective manufacturing. Bulk purchase discounts are common, and it's advisable to compare quotes from multiple suppliers. Understanding the market price for CAS 137076-22-3 will help in negotiating favorable terms.
  • Supplier Reputation: Choosing a reliable manufacturer or supplier is paramount. Look for companies with a proven track record, robust quality control systems, and transparent communication. Suppliers who offer certificates of analysis (CoA) and responsive customer service are preferred.
  • Packaging and Delivery: Standard packaging includes quantities like 25g, 100g, 500g, and bulk drums. Ensure the supplier can meet your specific packaging needs and that delivery timelines align with your project schedules. Factors like shipping costs from China also need to be considered.

Finding Reputable China Manufacturers for 1-Boc-piperidine-4-carboxaldehyde

China has emerged as a global hub for chemical manufacturing, offering a vast network of producers for pharmaceutical intermediates. When looking to buy 1-Boc-piperidine-4-carboxaldehyde, consider manufacturers that specialize in fine chemicals and pharmaceutical building blocks. Companies often highlight their CAS number (137076-22-3) and product purity prominently. Engaging directly with manufacturers can often lead to better pricing and more tailored solutions.

For instance, suppliers offering free samples can be a good starting point to evaluate product quality before committing to a larger purchase. Many leading China-based chemical suppliers are equipped to handle international orders, providing necessary documentation and support for customs clearance. Therefore, when searching for a manufacturer, focus on those with international export experience and a commitment to quality standards.

Conclusion: Securing Your Supply Chain for Essential Intermediates

Sourcing 1-Boc-piperidine-4-carboxaldehyde efficiently requires diligent research into potential suppliers, understanding product specifications, and negotiating competitive prices. By focusing on high purity, reliable supply chains, and trustworthy manufacturers, B2B buyers can ensure the smooth progression of their pharmaceutical research and development projects. If you are looking to purchase this essential intermediate, consider contacting established chemical suppliers in China to get quotes and samples, and build a robust partnership for your ongoing needs.