For procurement managers and R&D scientists in the pharmaceutical industry, securing a consistent supply of high-quality intermediates is paramount. One such critical compound is 2-Chloro-4-Methylpyrimidine, identified by CAS number 13036-57-2. This versatile molecule serves as a key building block in the synthesis of various Active Pharmaceutical Ingredients (APIs), notably playing a significant role as an intermediate for Dabrafenib Mesylate. Understanding where and how to buy this essential chemical can streamline your drug development process.

Why 2-Chloro-4-Methylpyrimidine is Essential

2-Chloro-4-Methylpyrimidine is a chlorinated pyrimidine derivative valued for its reactivity and structural contribution to complex organic molecules. Its precise molecular structure, C5H5ClN2, with a molecular weight of 128.56 g/mol, makes it an ideal starting material for advanced synthetic pathways. The demand for this intermediate is closely tied to the production of targeted therapies, such as those used in oncology, highlighting its importance in modern medicine. When looking to purchase, prioritizing suppliers who offer high purity levels, typically above 97% or 98%, is crucial for successful downstream reactions and the final API quality. Information regarding its physical state as a solid, with a melting point around 35-36°C, is also helpful for handling and storage considerations.

Navigating the Supplier Landscape: Choosing a Manufacturer in China

China has emerged as a global hub for chemical manufacturing, offering a vast network of suppliers for pharmaceutical intermediates. For companies seeking to buy 2-Chloro-4-Methylpyrimidine, partnering with a reputable Chinese manufacturer can offer significant advantages, including competitive pricing and large-scale production capabilities. When selecting a supplier, it's important to look for companies that adhere to international quality standards, such as GMP and ISO certifications, and can provide comprehensive documentation, including Certificates of Analysis (COA). These assurances are vital for regulatory compliance and the integrity of your pharmaceutical production. Furthermore, exploring suppliers who offer custom synthesis services can provide flexibility for unique project requirements.

Key Considerations When Purchasing

When inquiring about the price of 2-Chloro-4-Methylpyrimidine or placing an order, several factors should be clearly communicated. These include the required purity, quantity, desired packaging, and delivery timelines. For buyers aiming to secure a reliable source, establishing a long-term relationship with a manufacturer known for consistent product quality and responsive customer service is beneficial. Some suppliers also provide samples, allowing you to verify the product's suitability before committing to larger orders. As you research, consider the overall value proposition: a balance of cost, quality, and dependable supply. For example, a supplier offering transparent pricing and efficient logistics from China can significantly impact your project's budget and schedule.

In summary, sourcing 2-Chloro-4-Methylpyrimidine (CAS 13036-57-2) from experienced Chinese manufacturers is a strategic move for any pharmaceutical company. By focusing on purity, quality assurance, and reliable partnerships, procurement professionals can ensure they acquire this vital intermediate efficiently and cost-effectively, paving the way for successful API synthesis and drug development. For those looking to buy, inquire about availability and custom synthesis options from trusted manufacturers.